PICHAVANT, Loic; CARRIE, Helene; DURRIEU, Marie-Christine; HEROGUEZ, Valerie

doi:10.1039/C6PY01774F

Metadatos

Mostrar el registro completo del ítem

Licencia de uso del documento

PICHAVANT, Loic

CARRIE, Helene

DURRIEU, Marie-Christine

Idioma

Article de revue

Este ítem está publicado en

Polymer Chemistry. 2016

Resumen en inglés

Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces< Leer menos

Metadatos

Compartir este ítem

Licencia de uso del documento

Highly loaded nanoparticles with gentamicin sulfate by combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

Idioma

Este ítem está publicado en

Resumen en inglés

URI

DOI

Centros de investigación