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Highly loaded nanoparticles with gentamicin sulfate by combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

dc.contributor.authorPICHAVANT, Loic
dc.contributor.authorCARRIE, Helene
dc.contributor.authorDURRIEU, Marie-Christine
dc.contributor.authorHEROGUEZ, Valerie
dc.date.accessioned2020-09-03T07:56:09Z
dc.date.available2020-09-03T07:56:09Z
dc.date.issued2016
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/10831
dc.description.abstractEnAntibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces
dc.language.isoen
dc.title.enHighly loaded nanoparticles with gentamicin sulfate by combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials
dc.typeArticle de revue
dc.identifier.doi10.1039/C6PY01774F
dc.subject.halChimie/Matériaux
bordeaux.journalPolymer Chemistry
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN) - UMR 5248*
bordeaux.hal.laboratoriesInstitut de Chimie & de Biologie des Membranes & des Nano-objets (CBMN, UMR 5248)
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymer%20Chemistry&rft.date=2016&rft.au=PICHAVANT,%20Loic&CARRIE,%20Helene&DURRIEU,%20Marie-Christine&HEROGUEZ,%20Valerie&rft.genre=article


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