PICHAVANT, Loic; CARRIE, Helene; DURRIEU, Marie-Christine; HEROGUEZ, Valerie

doi:10.1039/C6PY01774F

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PICHAVANT, Loic

CARRIE, Helene

DURRIEU, Marie-Christine

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Polymer Chemistry. 2016

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Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces< Réduire

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Highly loaded nanoparticles with gentamicin sulfate by combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

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