MARTINS, Teresa P.; ROUGER, Caroline; GLASSER, Nathaniel R.; FREITAS, Sara; DE FRAISSINETTE, Nelly B.; BALSKUS, Emily P.; TASDEMIR, Deniz; LEÃO, Pedro N.

doi:10.1039/c8np00080h

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

MARTINS, Teresa P.

ROUGER, Caroline

Unité de Recherche Oenologie [Villenave d'Ornon] [OENO]

GLASSER, Nathaniel R.

Langue

Article de revue

Ce document a été publié dans

Natural Product Reports. 2019, vol. 36, n° 10, p. 1437-1461

Résumé en anglais

Covering: up to 2019 Alkylresorcinols are amphiphilic metabolites, well-known for their diverse biological activities, produced by both prokaryotes and eukaryotes. A few classes of alkylresorcinol scaffolds have been reported from the photoautotrophic cyanobacteria, ranging from the relatively simple hierridins to the more intricate cylindrocyclophanes. Recently, it has emerged that cyanobacteria employ two different biosynthetic pathways to produce unique alkylresorcinol scaffolds. However, these convergent pathways intersect by sharing biosynthetic elements which lead to common structural motifs. To obtain a broader view of the biochemical diversity of these compounds in cyanobacteria, we comprehensively cover the isolation, structure, biological activity and biosynthesis of their mono- and dialkylresorcinols. Moreover, we provide an overview of the diversity and distribution of alkylresorcinol-generating biosynthetic gene clusters in this phylum and highlight opportunities for discovery of novel alkylresorcinol scaffolds. Because some of these molecules have inspired notable syntheses, different approaches used to build these molecules in the laboratory are showcased.< Réduire

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols

Langue

Ce document a été publié dans

Résumé en anglais

URI

DOI

Unités de recherche