Interplay between a Foldamer Helix and a Macrocycle in a Foldarotaxane Architecture
Language
EN
Article de revue
This item was published in
Angewandte Chemie-International Edition. 2021, vol. 60, n° 15, p. 8380-8384
English Abstract
The design and synthesis of a novel rotaxane/foldaxane hybrid architecture is reported. The winding of an aromatic oligoamide helix host around a dumbbell-shaped thread-like guest, or axle, already surrounded by a macrocycle ...Read more >
The design and synthesis of a novel rotaxane/foldaxane hybrid architecture is reported. The winding of an aromatic oligoamide helix host around a dumbbell-shaped thread-like guest, or axle, already surrounded by a macrocycle was evidenced by NMR spectroscopy and X-ray crystallography. The process proved to depend on the position of the macrocycle along the axle and the associated steric hindrance. The macrocycle thus behaves as a switchable shield that modulates the affinity of the helix for the axle. Reciprocally, the foldamer helix acts as a supramolecular auxiliary that compartmentalizes the axle. In some cases, the macrocycle is forced to move along the axle to allow the foldamer to reach its best recognition site.Read less <
English Keywords
crystallography
foldamers
molecular motion
rotaxanes
Link to research data
ANR Project
Des FoldaRotaxanes pour la Synthèse généralisée de Molécules Entrelacées Improbables - ANR-17-CE07-0014