LODI, S.; PHILLIPS, A.; LUNDGREN, J.; LOGAN, R.; SHARMA, S.; COLE, S. R.; BABIKER, A.; LAW, M.; CHU, H.; BYRNE, D.; HORBAN, A.; STERNE, J. A. C.; PORTER, K.; SABIN, C.; COSTAGLIOLA, D.; ABGRALL, S.; GILL, J.; TOULOUMI, G.; PACHECO, A. G.; VAN SIGHEM, A.; REISS, P.; BUCHER, H. C.; MONTOLIU GIMENEZ, A.; JARRIN, I.; WITTKOP, Linda; MEYER, L.; PEREZ-HOYOS, S.; JUSTICE, A.; NEATON, J. D.; HERNAN, M. A.

doi:10.1093/aje/kwz100

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

Langue

Article de revue

Ce document a été publié dans

American journal of epidemiology. 2019-08-01, vol. 188, n° 8, p. 1569-1577

Résumé en anglais

Effect estimates from randomized trials and observational studies may not be directly comparable because of differences in study design, other than randomization, and in data analysis. We propose a three-step procedure to facilitate meaningful comparisons of effect estimates from randomized trials and observational studies: 1) harmonization of the study protocol (eligibility criteria, treatment strategies, outcome, start and end of follow-up, causal contrast) so that the studies target the same causal effect, 2) harmonization of the data analysis to estimate the causal effect, and 3) sensitivity analyses to investigate the impact of discrepancies that could not be accounted for in the harmonization process. To illustrate our approach, we compared estimates of the effect of immediate with deferred initiation of antiretroviral therapy in individuals positive to the human immunodeficiency virus from the START randomized trial and the observational HIV-CAUSAL Collaboration.< Réduire

Mots clés en anglais

MORPH3Eus

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Effect estimates in randomized trials and observational studies: comparing apples with apples

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche