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Effect estimates in randomized trials and observational studies: comparing apples with apples

dc.rights.licenseopenen_US
dc.contributor.authorLODI, S.
dc.contributor.authorPHILLIPS, A.
dc.contributor.authorLUNDGREN, J.
dc.contributor.authorLOGAN, R.
dc.contributor.authorSHARMA, S.
dc.contributor.authorCOLE, S. R.
dc.contributor.authorBABIKER, A.
dc.contributor.authorLAW, M.
dc.contributor.authorCHU, H.
dc.contributor.authorBYRNE, D.
dc.contributor.authorHORBAN, A.
dc.contributor.authorSTERNE, J. A. C.
dc.contributor.authorPORTER, K.
dc.contributor.authorSABIN, C.
dc.contributor.authorCOSTAGLIOLA, D.
dc.contributor.authorABGRALL, S.
dc.contributor.authorGILL, J.
dc.contributor.authorTOULOUMI, G.
dc.contributor.authorPACHECO, A. G.
dc.contributor.authorVAN SIGHEM, A.
dc.contributor.authorREISS, P.
dc.contributor.authorBUCHER, H. C.
dc.contributor.authorMONTOLIU GIMENEZ, A.
dc.contributor.authorJARRIN, I.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
dc.contributor.authorMEYER, L.
dc.contributor.authorPEREZ-HOYOS, S.
dc.contributor.authorJUSTICE, A.
dc.contributor.authorNEATON, J. D.
dc.contributor.authorHERNAN, M. A.
dc.date.accessioned2020-06-26T07:34:41Z
dc.date.available2020-06-26T07:34:41Z
dc.date.issued2019-08-01
dc.identifier.issn1476-6256 (Electronic) 0002-9262 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/8206
dc.description.abstractEnEffect estimates from randomized trials and observational studies may not be directly comparable because of differences in study design, other than randomization, and in data analysis. We propose a three-step procedure to facilitate meaningful comparisons of effect estimates from randomized trials and observational studies: 1) harmonization of the study protocol (eligibility criteria, treatment strategies, outcome, start and end of follow-up, causal contrast) so that the studies target the same causal effect, 2) harmonization of the data analysis to estimate the causal effect, and 3) sensitivity analyses to investigate the impact of discrepancies that could not be accounted for in the harmonization process. To illustrate our approach, we compared estimates of the effect of immediate with deferred initiation of antiretroviral therapy in individuals positive to the human immunodeficiency virus from the START randomized trial and the observational HIV-CAUSAL Collaboration.
dc.language.isoENen_US
dc.subject.enMORPH3Eus
dc.title.enEffect estimates in randomized trials and observational studies: comparing apples with apples
dc.title.alternativeAm J Epidemiolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/aje/kwz100en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed31063192en_US
bordeaux.journalAmerican journal of epidemiologyen_US
bordeaux.page1569-1577en_US
bordeaux.volume188en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - U1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
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