Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
OUATTARA, Alexandre
Service Anesthésie - Réanimation [Bordeaux]
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
< Reduce
Service Anesthésie - Réanimation [Bordeaux]
Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
Language
en
Article de revue
This item was published in
Annals of Intensive Care. 2017-12, vol. 7, n° 1, p. 115
SpringerOpen
English Abstract
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum ...Read more >
Beyond haemostasis, platelets have emerged as versatile effectors of the immune response. The contribution of platelets in inflammation, tissue integrity and defence against infections has considerably widened the spectrum of their role in health and disease. Here, we propose a narrative review that first describes these new platelet attributes. We then examine their relevance to microcirculatory alterations in multi-organ dysfunction, a major sepsis complication. Rapid progresses that are made on the knowledge of novel platelet functions should improve the understanding of thrombocytopenia, a common condition and a predictor of adverse outcome in sepsis, and may provide potential avenues for management and therapy.Read less <
Origin
Hal importedCollections