Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L.
| dc.rights.license | open | en_US |
| dc.contributor.author | GHRIBI, Lotfi | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | WAFFO TEGUO, Pierre | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | CLUZET, Stephanie | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | MARCHAL, Axel
IDREF: 150146477 | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | MARQUES, Jessica | |
| hal.structure.identifier | Unité de Recherche Oenologie [Villenave d'Ornon] [OENO] | |
| dc.contributor.author | MERILLON, Jean-Michel | |
| dc.contributor.author | BEN JANNET, Hichem | |
| dc.date.accessioned | 2021-05-21T16:05:41Z | |
| dc.date.available | 2021-05-21T16:05:41Z | |
| dc.date.issued | 2015-09-15 | |
| dc.identifier.issn | 1464-3405 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/78601 | |
| dc.description.abstractEn | A phytochemical investigation of the roots of Ononis angustissima L. (Fabaceae) offered to the bio-guided isolation of new isoflavone 3-(4-(glucopyranosyloxy)-5-hydroxy-2-methoxyphenyl)-7-hydroxy-4H-chromen-4-one 1, together with nine known compounds, ononin 2, formononetin 3, (+)-puerol A-2'-O-β-D-glucose 4, (-)-puerol B-2'-O-β-D-glucopyranose ((-)-sophoraside A) 5, (+)-puerol A 6, (-)-trifolirhizin 7, (-)-trifolirhizin-6'-O-malonate 8, (-)-maackiain 9 and (-)-medicarpin 10. Compounds 2-10 were isolated and identified for the first time in Ononis angustissima. We investigated antioxidant capacities of isolated molecules and results showed that compound 6 exhibited the highest antioxidant activity with IC50 values of 19.53 μg/mL, 28.29 μg/mL and 38.53 μg/mL by DPPH radical, ABTS radical cation and reducing power assay, respectively, and an interesting IC50 (20.45 μg/mL) of 1 against DPPH. In addition, the neuroprotective activity of six isolated molecules (4-7, 9, 10) were evaluated. Following the exposure of PC12 cells to Aβ25-35, compounds 9 and 10 triggered a significant increase of cell viability and in a dose dependent manner. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Antioxidants | |
| dc.subject.en | Benzothiazoles | |
| dc.subject.en | Biphenyl Compounds | |
| dc.subject.en | Cell Survival | |
| dc.subject.en | Dose-Response Relationship | |
| dc.subject.en | Drug | |
| dc.subject.en | Free Radicals | |
| dc.subject.en | Molecular Structure | |
| dc.subject.en | Ononis | |
| dc.subject.en | PC12 Cells | |
| dc.subject.en | Picrates | |
| dc.subject.en | Plant Extracts | |
| dc.subject.en | Plant Roots | |
| dc.subject.en | Rats | |
| dc.subject.en | Structure-Activity Relationship | |
| dc.subject.en | Sulfonic Acids | |
| dc.subject.en | Tunisia | |
| dc.title.en | Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L. | |
| dc.title.alternative | Bioorg Med Chem Lett | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.bmcl.2015.07.076 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Biologie végétale | en_US |
| dc.identifier.pubmed | 26248805 | en_US |
| bordeaux.journal | Bioorganic and Medicinal Chemistry Letters | en_US |
| bordeaux.page | 3825-30 | en_US |
| bordeaux.volume | 25 | en_US |
| bordeaux.hal.laboratories | Unité de Recherche Oenologie - EA 4577 | en_US |
| bordeaux.issue | 18 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.export | false | |
| workflow.import.source | pubmed | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Bioorganic%20and%20Medicinal%20Chemistry%20Letters&rft.date=2015-09-15&rft.volume=25&rft.issue=18&rft.spage=3825-30&rft.epage=3825-30&rft.eissn=1464-3405&rft.issn=1464-3405&rft.au=GHRIBI,%20Lotfi&WAFFO%20TEGUO,%20Pierre&CLUZET,%20Stephanie&MARCHAL,%20Axel&MARQUES,%20Jessica&rft.genre=article |
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