Quantification of tablet sensitivity to a stress concentration: Generalization of Hiestand's approach and link with the microstructure
Language
en
Article de revue
This item was published in
Powder Technology. 2020-06, vol. 369, p. 176-183
Elsevier
English Abstract
Sensitivity to a stress concentration is important for the development of pharmaceutical tablets as it is related to defects like capping. The Brittle Fracture Index (BFI) was introduced by Hiestand et al. to test this ...Read more >
Sensitivity to a stress concentration is important for the development of pharmaceutical tablets as it is related to defects like capping. The Brittle Fracture Index (BFI) was introduced by Hiestand et al. to test this sensitivity. Recently, a more general index, based on the average stress criterion, was proposed as a generalized Hiestand approach. In this work, this new approach is tested on tablets obtained for several products and pressure levels, and results show the wide applicability of the new criterion. Furthermore, X-ray micro-computed tomography was used to link the tablet microstructure and the sensitivity to a stress concentration. A strong correlation was found between the size of the largest pores in the structure and the value of a(0) which quantify the sensitivity to a stress concentration in the generalized Hiestand approach. These results constitute the first attempt to link the brittle fracture propensity of tablets with their effective microstructure.Read less <
English Keywords
Tabletting
Capping
BFI
Brittle fracture propensity
Microstructure
X mu CT
Origin
Hal imported