A new HIV-1 circulating recombinant form (CRF98_cpx) between CRF06_cpx and subtype B identified in Southwestern France
Language
EN
Article de revue
This item was published in
AIDS Research and Human Retroviruses. 2018-11, vol. 34, n° 11, p. 1005-1009
English Abstract
During a recent study on the sequencing data of our database between 2012 and 2016 in Southwestern France, we observed that 8 patients harbored what seemed to be the same virus. Indeed, routine genotyping at the time of ...Read more >
During a recent study on the sequencing data of our database between 2012 and 2016 in Southwestern France, we observed that 8 patients harbored what seemed to be the same virus. Indeed, routine genotyping at the time of HIV diagnosis showed that protease (Prot) and reverse transcriptase (RT) were related to CRF06_cpx and subtype B, respectively. The integrase (INT) sequences (available for 3 patients) were clustering with CRF06_cpx and envelope (Env) gp120 sequences (available for 2 patients) with subtype B. Since such a recombinant has not been recorded in the Los Alamos database, we decided to characterize the full-length genome of this virus. The data suggest the identification of a new CRF between CRF06_cpx and subtype B, the structure of which is very complex with multiple breakpoints. We will refer this CRF as CRF98_cpx.Read less <
English Keywords
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