RECORDON-PINSON, P.; ALVES, B. M.; TUMIOTTO, C.; BELLECAVE, P.; BONNET, Fabrice; NEAU, D.; SOARES, E. A.; SOARES, M. A.; FLEURY, H.

doi:10.1089/aid.2018.0122

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AIDS Research and Human Retroviruses. 2018-11, vol. 34, n° 11, p. 1005-1009

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During a recent study on the sequencing data of our database between 2012 and 2016 in Southwestern France, we observed that 8 patients harbored what seemed to be the same virus. Indeed, routine genotyping at the time of HIV diagnosis showed that protease (Prot) and reverse transcriptase (RT) were related to CRF06_cpx and subtype B, respectively. The integrase (INT) sequences (available for 3 patients) were clustering with CRF06_cpx and envelope (Env) gp120 sequences (available for 2 patients) with subtype B. Since such a recombinant has not been recorded in the Los Alamos database, we decided to characterize the full-length genome of this virus. The data suggest the identification of a new CRF between CRF06_cpx and subtype B, the structure of which is very complex with multiple breakpoints. We will refer this CRF as CRF98_cpx.< Réduire

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A new HIV-1 circulating recombinant form (CRF98_cpx) between CRF06_cpx and subtype B identified in Southwestern France

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