Responsive micelles and vesicles based on polypeptide diblock copolymers
RODRIGUEZ-HERNANDEZ, Juan
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
GNANOU, Yves
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
See more >
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
RODRIGUEZ-HERNANDEZ, Juan
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
GNANOU, Yves
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des polymères organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des polymères organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
< Reduce
Laboratoire de Chimie des polymères organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Language
en
Article de revue
This item was published in
Polymers for Advanced Technologies. 2006, vol. 17, n° 9-10, p. 782-785
Wiley
English Abstract
The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive ...Read more >
The self-assembly of well-defined polypeptide-based diblock copolymers into micelles and vesicles is presented. The stimuli-responsive behavior of polypeptides to pH and ionic strength is used to produce stimuli-responsive nanoparticles with a control size and shape. Results focusing on vesicles obtained from polypeptide-based diblock copolymers that are particularly promising for biomedical application will be detailed by means of static and dynamic light scattering analysis, UV circular dichroism, NMR and small angle neutron scattering experiments. Also systems that are able to form vesicles with narrow size distributions at basic and acidic pH going through an intermediate state of single polymer chains are presented. These nanoparticles are particularly interesting for encapsulation and delivery purposes at a controlled pH. Finally, surface self-assembly of micelles and vesicles will be shown as models for biological surfaces such as mucosal surfaces.Read less <
English Keywords
responsive
vesicles
polypeptide
block copolymers
self-assembly
Origin
Hal imported