Metadata
Show full item recordShare this item!
Genetic labeling of embryonically-born dentate granule neurons in young mice using the PenkCre mouse line
MORTESSAGNE, Pierre
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
CARTIER, Estelle
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
See more >
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
MORTESSAGNE, Pierre
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
CARTIER, Estelle
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
FÈVRE, Murielle
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
CORAILLER, Fiona
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
ABROUS, Djoher Nora
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
PACARY, Emilie
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Language
EN
Article de revue
This item was published in
Scientific Reports. 2024-02-29, vol. 14, n° 1, p. 5022
English Abstract
The dentate gyrus (DG) of the hippocampus is a mosaic of dentate granule neurons (DGNs) accumulated throughout life. While many studies focused on the morpho-functional properties of adult-born DGNs, much less is known ...Read more >
The dentate gyrus (DG) of the hippocampus is a mosaic of dentate granule neurons (DGNs) accumulated throughout life. While many studies focused on the morpho-functional properties of adult-born DGNs, much less is known about DGNs generated during development, and in particular those born during embryogenesis. One of the main reasons for this gap is the lack of methods available to specifically label and manipulate embryonically-born DGNs. Here, we have assessed the relevance of the PenkCre mouse line as a genetic model to target this embryonically-born population. In young animals, PenkCre expression allows to tag neurons in the DG with positional, morphological and electrophysiological properties characteristic of DGNs born during the embryonic period. In addition, PenkCre+ cells in the DG are distributed in both blades along the entire septo-temporal axis. This model thus offers new possibilities to explore the functions of this underexplored population of embryonically-born DGNs. © The Author(s) 2024.Read less <
English Keywords
Animals
Dentate Gyrus / physiology
Hippocampus
Mice
Neurogenesis / physiology
Neurons / physiology
ANR Project
Développement et fonction des nouveaux neurones dans l'hippocampe adulte: exploration du rôle clé joué par Rnd2
Rôle de l'organisation à l'échelle nanométrique des récepteurs NMDA dans le développement normal du cerveau et les troubles GRIN.
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Développment d'une infrastructure française distribuée coordonnée
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003
Rôle de l'organisation à l'échelle nanométrique des récepteurs NMDA dans le développement normal du cerveau et les troubles GRIN.
Bordeaux Region Aquitaine Initiative for Neuroscience - ANR-10-LABX-0043
Développment d'une infrastructure française distribuée coordonnée
Initiative d'excellence de l'Université de Bordeaux - ANR-10-IDEX-0003