The serotonin2B receptor and neurochemical regulation in the brain
SPAMPINATO, Umberto
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
CATHALA, Adeline
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
DEVROYE, Celine
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
SPAMPINATO, Umberto
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
CATHALA, Adeline
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
DEVROYE, Celine
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Language
EN
Chapitre d'ouvrage
This item was published in
Handbook of the Behavioral Neurobiology of Serotonin. 2020, vol. 31, p. 147-156
Elsevier
English Abstract
The serotonin2B receptor (5-HT2BR) is the most recent addition to the 5-HT2R family. During the last decade, a growing number of studies have shown that the central 5-HT2BR participates in the control of dopamine (DA) and ...Read more >
The serotonin2B receptor (5-HT2BR) is the most recent addition to the 5-HT2R family. During the last decade, a growing number of studies have shown that the central 5-HT2BR participates in the control of dopamine (DA) and serotonin (5-HT) neuron activity, thereby highlighting its key role for future therapeutic strategies of DA-related neuropsychiatric disorders. This chapter, after a reminder of the 5-HT2BR expression in the central nervous system and the 5-HT2BR agonists and antagonists available today, will focus on the role of this receptor in the control of 5-HT and DA activity in the rodent brain, by encompassing electrophysiological and neurochemical data issued from in vitro and in vivo studies. This overview will provide a functional basis to understand the therapeutic relevance of this receptor for treating DA-dependent neuropsychiatric disorders such as schizophrenia and drug addiction. © 2020 Elsevier B.V.Read less <
English Keywords
Serotonin 2b Receptor
Binding Affinity
Brain
Central Nervous System
Dorsal Raphe Nucleus
Drug Dependence
Human
Interneuron
Medial Prefrontal Cortex
Mental Disease
Nerve Cell
Neurochemistry
Neuropharmacology
Nonhuman
Pyramidal Nerve Cell
Schizophrenia
Ventral Tegmentum
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