MAZEL, Vincent; GARCIA, Cleo; TCHORELOFF, Pierre

doi:10.1016/j.ijpharm.2023.123365

Institut de Mécanique et d'Ingénierie [I2M]

GARCIA, Cleo

TCHORELOFF, Pierre

Institut de Mécanique et d'Ingénierie [I2M]

Langue

Article de revue

Ce document a été publié dans

International Journal of Pharmaceutics. 2023-10-15, vol. 645, p. 123365

Résumé en anglais

Capping is a common industrial issue during the manufacturing of pharmaceutical tablets. It is influenced by both process and formulation parameters. In this work, a systematic study of the influence of the geometrical features of biconvex tablets on capping occurrence was performed on a model formulation, using a design of experiment. Capping was characterized by the pressure at which half of the produced tablets were capped. The influence of the tablet geometry was assessed by varying three parameters: the diameter (D), the band thickness (W) and the ratio between the radius of curvature (R) and the diameter, i.e. R/D. Results showed that having a large diameter, a low band thickness and a high curvature (i.e. a low R/D) favored capping occurrence. Moreover, the effects are not independent as cross-effect were detected. Finally, even for homothetic tablets (i.e. same R/D and W/D) it is shown that a large diameter increases capping occurrence. These results could be used in the future as a guideline for punch selection during tablet development.< Réduire

Mots clés en anglais

Tablet

Capping

DoE

Tabletting

Punch shape

Curvature

URI

https://oskar-bordeaux.fr/handle/20.500.12278/204557

DOI

http://dx.doi.org/10.1016/j.ijpharm.2023.123365

Unités de recherche

Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295

Voir/Ouvrir

Métadonnées

Partager cette publication !

Licence d’utilisation du document

Effect of geometrical features on the capping behavior of biconvex tablets.

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

URI

DOI

Unités de recherche