Effect of geometrical features on the capping behavior of biconvex tablets.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | MAZEL, Vincent
IDREF: 113057954 | |
| dc.contributor.author | GARCIA, Cleo | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | TCHORELOFF, Pierre
IDREF: 069233624 | |
| dc.date.accessioned | 2025-01-24T13:44:22Z | |
| dc.date.available | 2025-01-24T13:44:22Z | |
| dc.date.issued | 2023-10-15 | |
| dc.identifier.issn | 1873-3476 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204557 | |
| dc.description.abstractEn | Capping is a common industrial issue during the manufacturing of pharmaceutical tablets. It is influenced by both process and formulation parameters. In this work, a systematic study of the influence of the geometrical features of biconvex tablets on capping occurrence was performed on a model formulation, using a design of experiment. Capping was characterized by the pressure at which half of the produced tablets were capped. The influence of the tablet geometry was assessed by varying three parameters: the diameter (D), the band thickness (W) and the ratio between the radius of curvature (R) and the diameter, i.e. R/D. Results showed that having a large diameter, a low band thickness and a high curvature (i.e. a low R/D) favored capping occurrence. Moreover, the effects are not independent as cross-effect were detected. Finally, even for homothetic tablets (i.e. same R/D and W/D) it is shown that a large diameter increases capping occurrence. These results could be used in the future as a guideline for punch selection during tablet development. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Tablet | |
| dc.subject.en | Capping | |
| dc.subject.en | DoE | |
| dc.subject.en | Tabletting | |
| dc.subject.en | Punch shape | |
| dc.subject.en | Curvature | |
| dc.title.en | Effect of geometrical features on the capping behavior of biconvex tablets. | |
| dc.title.alternative | Int J Pharm | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.ijpharm.2023.123365 | en_US |
| dc.identifier.pubmed | 37661032 | en_US |
| bordeaux.journal | International Journal of Pharmaceutics | en_US |
| bordeaux.page | 123365 | en_US |
| bordeaux.volume | 645 | en_US |
| bordeaux.hal.laboratories | Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | Arts et Métiers | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
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| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
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