HSEIN, Hassana; MADI, Charbel; MAZEL, Vincent; TCHORELOFF, Pierre; BUSIGNIES, Virginie

doi:10.1016/j.ijpharm.2023.123598

Institut de Mécanique et d'Ingénierie [I2M]

MADI, Charbel
Institut de Mécanique et d'Ingénierie [I2M]

MAZEL, Vincent

Institut de Mécanique et d'Ingénierie [I2M]

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Article de revue

Ce document a été publié dans

International Journal of Pharmaceutics. 2023-12-15, vol. 648, p. 123598

Résumé en anglais

Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route are used to treat local diseases particularly in the gastro-intestinal tract. Therefore, many studies concentrate nowadays their effort on developing alternative dosage forms to deliver biopharmaceutical molecules by the oral route. Tablets are the most popular solid pharmaceutical dosage form used for oral administration since they present many advantages, but poor informations are available on the possibility of tableting freeze-dried powders. In this study, we evaluate the compaction behavior of freeze-dried trehalose powder since trehalose is one of the most used cryo and lyoprotectant for the lyophilisation of biopharmaceutical entities. Results show that freeze-dried trehalose powder can be tableted while remaining amorphous and the obtained compacts present very specific properties in terms of compressibility, tabletability, brittleness and viscoelasticity compared to the crystalline trehalose and compared to classical pharmaceutical excipients.< Réduire

Mots clés en anglais

Trehalose

Chemistry

Pharmaceutical

Powders

Drug Stability

Freeze Drying

Biological Products

URI

https://oskar-bordeaux.fr/handle/20.500.12278/204555

DOI

http://dx.doi.org/10.1016/j.ijpharm.2023.123598

Unités de recherche

Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295

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Tableting properties of freeze-dried trehalose: Physico-chemical and mechanical investigation.

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Résumé en anglais

Mots clés en anglais

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DOI

Unités de recherche