Tableting properties of freeze-dried trehalose: Physico-chemical and mechanical investigation.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | HSEIN, Hassana | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | MADI, Charbel | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | MAZEL, Vincent
IDREF: 113057954 | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | TCHORELOFF, Pierre
IDREF: 069233624 | |
| hal.structure.identifier | Institut de Mécanique et d'Ingénierie [I2M] | |
| dc.contributor.author | BUSIGNIES, Virginie
IDREF: 07355247X | |
| dc.date.accessioned | 2025-01-24T13:13:42Z | |
| dc.date.available | 2025-01-24T13:13:42Z | |
| dc.date.issued | 2023-12-15 | |
| dc.identifier.issn | 1873-3476 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/204555 | |
| dc.description.abstractEn | Freeze-drying of biopharmaceutical products is the method of choice in order to improve their stability and storage conditions. Such freeze-dried products are usually intended for parenteral route administration. However, many biopharmaceutical materials administered by parenteral route are used to treat local diseases particularly in the gastro-intestinal tract. Therefore, many studies concentrate nowadays their effort on developing alternative dosage forms to deliver biopharmaceutical molecules by the oral route. Tablets are the most popular solid pharmaceutical dosage form used for oral administration since they present many advantages, but poor informations are available on the possibility of tableting freeze-dried powders. In this study, we evaluate the compaction behavior of freeze-dried trehalose powder since trehalose is one of the most used cryo and lyoprotectant for the lyophilisation of biopharmaceutical entities. Results show that freeze-dried trehalose powder can be tableted while remaining amorphous and the obtained compacts present very specific properties in terms of compressibility, tabletability, brittleness and viscoelasticity compared to the crystalline trehalose and compared to classical pharmaceutical excipients. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Trehalose | |
| dc.subject.en | Chemistry | |
| dc.subject.en | Pharmaceutical | |
| dc.subject.en | Powders | |
| dc.subject.en | Drug Stability | |
| dc.subject.en | Freeze Drying | |
| dc.subject.en | Biological Products | |
| dc.title.en | Tableting properties of freeze-dried trehalose: Physico-chemical and mechanical investigation. | |
| dc.title.alternative | Int J Pharm | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.ijpharm.2023.123598 | en_US |
| dc.identifier.pubmed | 37956724 | en_US |
| bordeaux.journal | International Journal of Pharmaceutics | en_US |
| bordeaux.page | 123598 | en_US |
| bordeaux.volume | 648 | en_US |
| bordeaux.hal.laboratories | Institut de Mécanique et d’Ingénierie de Bordeaux (I2M) - UMR 5295 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | Bordeaux INP | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.institution | INRAE | en_US |
| bordeaux.institution | Arts et Métiers | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
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| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
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| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
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