Nanoparticles Produced by Ring-Opening Metathesis Polymerization Using Norbornenyl-poly(ethylene oxide) as a Ligand-Free Generic Platform for Highly Selective In Vivo Tumor Targeting
GUEUGNON, Fabien
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
POULIQUEN, Daniel
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
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Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
GUEUGNON, Fabien
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
POULIQUEN, Daniel
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
COLLETTE, Floraine
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
DELATOUCHE, Régis
Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
HÉROGUEZ, Valérie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
BERTRAND, Philippe
Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
Institut de chimie des milieux et matériaux de Poitiers [UMR 7285] [IC2MP [Poitiers]]
BLANQUART, Christophe
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
< Reduce
Centre de Recherche en Cancérologie Nantes-Angers [CRCNA]
Université de Nantes [UN]
Language
en
Article de revue
This item was published in
Biomacromolecules. 2013, vol. 14, n° 7, p. 2396-2402
American Chemical Society
English Abstract
We described a norbornenyl-poly(ethylene oxide) nanoparticles ligand-free generic platform, made fluorescent with straightforward preparation by ring-opening metathesis polymerization (ROMP). Our method allowed to easily ...Read more >
We described a norbornenyl-poly(ethylene oxide) nanoparticles ligand-free generic platform, made fluorescent with straightforward preparation by ring-opening metathesis polymerization (ROMP). Our method allowed to easily obtain a drug delivery system (DDS) with facilitated functionalization by means of azide-alkyne click chemistry and with a high selectivity for the tumor in vivo, while cellular internalization is obtained without cell targeting strategy. We demonstrated that our nanoparticles are internalized by endocytosis and colocalized with acidic intracellular compartments in two models of aggressive tumoral cell lines with low prognostic and limited therapeutic treatments. Our nanoparticles could be of real interest to limit the toxicity and to increase the clinical benefit of drugs suffering rapid clearance and side effects and an alternative for cancers with poorly efficient therapeutic solutions by associating the drug delivery in the tumor tissue with an acid-sensitive release system.Read less <
English Keywords
PARTICLES
IDENTIFICATION
ADENOCARCINOMA
POLYMERS
ROMP
BLOCK-COPOLYMERS
DRUG-DELIVERY
CLICK CHEMISTRY
MALIGNANT PLEURAL MESOTHELIOMA
CELL
Origin
Hal imported