GARCÍA-MARÍN, Luis M; CAMPOS, Adrian I; DIAZ-TORRES, Santiago; RABINOWITZ, Jill A; CEJA, Zuriel; MITCHELL, Brittany L; GRASBY, Katrina L; THORP, Jackson G; AGARTZ, Ingrid; ALHUSAINI, Saud; AMES, David; AMOUYEL, Philippe; ANDREASSEN, Ole A; ARFANAKIS, Konstantinos; ARIAS-VASQUEZ, Alejandro; ARMSTRONG, Nicola J; ATHANASIU, Lavinia; BASTIN, Mark E; BEISER, Alexa S; BENNETT, David A; BIS, Joshua C; BOKS, Marco P M; BOOMSMA, Dorret I; BRODATY, Henry; BROUWER, Rachel M; BUITELAAR, Jan K; BURKHARDT, Ralph; CAHN, Wiepke; CALHOUN, Vince D; CARMICHAEL, Owen T; CHAKRAVARTY, Mallar; CHEN, Qiang; CHING, Christopher R K; CICHON, Sven; CRESPO-FACORRO, Benedicto; CRIVELLO, Fabrice; DALE, Anders M; SMITH, George Davey; DE GEUS, Eco J C; DE JAGER, Philip L; DE ZUBICARAY, Greig I; DEBETTE, Stephanie; DECARLI, Charles; DEPONDT, Chantal; DESRIVIÈRES, Sylvane; DJUROVIC, Srdjan; EHRLICH, Stefan; ERK, Susanne; ESPESETH, Thomas; FERNÁNDEZ, Guillén; FILIPPI, Irina; FISHER, Simon E; FLEISCHMAN, Debra A; FLETCHER, Evan; FORNAGE, Myriam; FORSTNER, Andreas J; FRANCKS, Clyde; FRANKE, Barbara; GE, Tian; GOLDMAN, Aaron L; GRABE, Hans J; GREEN, Robert C; GRIMM, Oliver; GROENEWOLD, Nynke A; GRUBER, Oliver; GUDNASON, Vilmundur; HÅBERG, Asta K; HAUKVIK, Unn K; HEINZ, Andreas; HIBAR, Derrek P; HILAL, Saima; HIMALI, Jayandra J; HO, Beng-Choon; HOEHN, David F; HOEKSTRA, Pieter J; HOFER, Edith; HOFFMANN, Wolfgang; HOLMES, Avram J; HOMUTH, Georg; HOSTEN, Norbert; IKRAM, M Kamran; IPSER, Jonathan C; JACK, Clifford R; JAHANSHAD, Neda; JÖNSSON, Erik G; KAHN, Rene S; KANAI, Ryota; KLEIN, Marieke; KNOL, Maria J; LAUNER, Lenore J; LAWRIE, Stephen M; HELLARD, Stephanie Le; LEE, Phil H; LEMAÎTRE, Hervé; LI, Shuo; LIEWALD, David C M; LIN, Honghuang; LONGSTRETH, W T; LOPEZ, Oscar L; LUCIANO, Michelle; MAILLARD, Pauline; MARQUAND, Andre F; MARTIN, Nicholas G; MARTINOT, Jean-Luc; MATHER, Karen A; MATTAY, Venkata S; MCMAHON, Katie L; MECOCCI, Patrizia; MELLE, Ingrid; MEYER-LINDENBERG, Andreas; MIRZA-SCHREIBER, Nazanin; MILANESCHI, Yuri; MOSLEY, Thomas H; MÜHLEISEN, Thomas W; MÜLLER-MYHSOK, Bertram; MANIEGA, Susana Muñoz; NAUCK, Matthias; NHO, Kwangsik; NIESSEN, Wiro J; NÖTHEN, Markus M; NYQUIST, Paul A; OOSTERLAAN, Jaap; PANDOLFO, Massimo; PAUS, Tomas; PAUSOVA, Zdenka; PENNINX, Brenda W J H; PIKE, G Bruce; PSATY, Bruce M; PÜTZ, Benno; REPPERMUND, Simone; RIETSCHEL, Marcella D; RISACHER, Shannon L; ROMANCZUK-SEIFERTH, Nina; ROMERO-GARCIA, Rafael; ROSHCHUPKIN, Gennady V; ROTTER, Jerome I; SACHDEV, Perminder S; SÄMANN, Philipp G; SAREMI, Arvin; SARGURUPREMRAJ, Muralidharan; SAYKIN, Andrew J; SCHMAAL, Lianne; SCHMIDT, Helena; SCHMIDT, Reinhold; SCHOFIELD, Peter R; SCHOLZ, Markus; SCHUMANN, Gunter; SCHWARZ, Emanuel; SHEN, Li; SHIN, Jean; SISODIYA, Sanjay M; SMITH, Albert V; SMOLLER, Jordan W; SOININEN, Hilkka S; STEEN, Vidar M; STEIN, Dan J; STEIN, Jason L; THOMOPOULOS, Sophia I; TOGA, Arthur W; TORDESILLAS-GUTIÉRREZ, Diana; TROLLOR, Julian N; VALDES-HERNANDEZ, Maria C; VAN T ENT, Dennis; VAN BOKHOVEN, Hans; VAN DER MEER, Dennis; VAN DER WEE, Nic J A; VÁZQUEZ-BOURGON, Javier; VELTMAN, Dick J; VERNOOIJ, Meike W; VILLRINGER, Arno; VINKE, Louis N; VÖLZKE, Henry; WALTER, Henrik; WARDLAW, Joanna M; WEINBERGER, Daniel R; WEINER, Michael W; WEN, Wei; WESTLYE, Lars T; WESTMAN, Eric; WHITE, Tonya; WITTE, A Veronica; WOLF, Christiane; YANG, Jingyun; ZWIERS, Marcel P; IKRAM, M Arfan; SESHADRI, Sudha; THOMPSON, Paul M; SATIZABAL, Claudia L; MEDLAND, Sarah E; RENTERÍA, Miguel E

doi:10.1038/s41588-024-01951-z

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GARCÍA-MARÍN, Luis M

CAMPOS, Adrian I

DIAZ-TORRES, Santiago

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Article de revue

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Nature Genetics. 2024-11-01, vol. 56, n° 11, p. 2333-2344

Resumen en inglés

Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and attention-deficit/hyperactivity disorder. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.< Leer menos

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Humans

Genome-Wide Association Study

Multifactorial Inheritance

Brain

Female

Male

Organ Size

Attention Deficit Disorder with Hyperactivity

Parkinson Disease

Polymorphism

Single Nucleotide

Genomics

Adult

Genetic Predisposition to Disease

Middle Aged

White People

URI

https://oskar-bordeaux.fr/handle/20.500.12278/203440

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http://dx.doi.org/10.1038/s41588-024-01951-z

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Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

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Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

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Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación