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Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.

dc.rights.licenseopenen_US
dc.contributor.authorGARCÍA-MARÍN, Luis M
dc.contributor.authorCAMPOS, Adrian I
dc.contributor.authorDIAZ-TORRES, Santiago
dc.contributor.authorRABINOWITZ, Jill A
dc.contributor.authorCEJA, Zuriel
dc.contributor.authorMITCHELL, Brittany L
dc.contributor.authorGRASBY, Katrina L
dc.contributor.authorTHORP, Jackson G
dc.contributor.authorAGARTZ, Ingrid
dc.contributor.authorALHUSAINI, Saud
dc.contributor.authorAMES, David
dc.contributor.authorAMOUYEL, Philippe
dc.contributor.authorANDREASSEN, Ole A
dc.contributor.authorARFANAKIS, Konstantinos
dc.contributor.authorARIAS-VASQUEZ, Alejandro
dc.contributor.authorARMSTRONG, Nicola J
dc.contributor.authorATHANASIU, Lavinia
dc.contributor.authorBASTIN, Mark E
dc.contributor.authorBEISER, Alexa S
dc.contributor.authorBENNETT, David A
dc.contributor.authorBIS, Joshua C
dc.contributor.authorBOKS, Marco P M
dc.contributor.authorBOOMSMA, Dorret I
dc.contributor.authorBRODATY, Henry
dc.contributor.authorBROUWER, Rachel M
dc.contributor.authorBUITELAAR, Jan K
dc.contributor.authorBURKHARDT, Ralph
dc.contributor.authorCAHN, Wiepke
dc.contributor.authorCALHOUN, Vince D
dc.contributor.authorCARMICHAEL, Owen T
dc.contributor.authorCHAKRAVARTY, Mallar
dc.contributor.authorCHEN, Qiang
dc.contributor.authorCHING, Christopher R K
dc.contributor.authorCICHON, Sven
dc.contributor.authorCRESPO-FACORRO, Benedicto
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorCRIVELLO, Fabrice
dc.contributor.authorDALE, Anders M
dc.contributor.authorSMITH, George Davey
dc.contributor.authorDE GEUS, Eco J C
dc.contributor.authorDE JAGER, Philip L
dc.contributor.authorDE ZUBICARAY, Greig I
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDECARLI, Charles
dc.contributor.authorDEPONDT, Chantal
dc.contributor.authorDESRIVIÈRES, Sylvane
dc.contributor.authorDJUROVIC, Srdjan
dc.contributor.authorEHRLICH, Stefan
dc.contributor.authorERK, Susanne
dc.contributor.authorESPESETH, Thomas
dc.contributor.authorFERNÁNDEZ, Guillén
dc.contributor.authorFILIPPI, Irina
dc.contributor.authorFISHER, Simon E
dc.contributor.authorFLEISCHMAN, Debra A
dc.contributor.authorFLETCHER, Evan
dc.contributor.authorFORNAGE, Myriam
dc.contributor.authorFORSTNER, Andreas J
dc.contributor.authorFRANCKS, Clyde
dc.contributor.authorFRANKE, Barbara
dc.contributor.authorGE, Tian
dc.contributor.authorGOLDMAN, Aaron L
dc.contributor.authorGRABE, Hans J
dc.contributor.authorGREEN, Robert C
dc.contributor.authorGRIMM, Oliver
dc.contributor.authorGROENEWOLD, Nynke A
dc.contributor.authorGRUBER, Oliver
dc.contributor.authorGUDNASON, Vilmundur
dc.contributor.authorHÅBERG, Asta K
dc.contributor.authorHAUKVIK, Unn K
dc.contributor.authorHEINZ, Andreas
dc.contributor.authorHIBAR, Derrek P
dc.contributor.authorHILAL, Saima
dc.contributor.authorHIMALI, Jayandra J
dc.contributor.authorHO, Beng-Choon
dc.contributor.authorHOEHN, David F
dc.contributor.authorHOEKSTRA, Pieter J
dc.contributor.authorHOFER, Edith
dc.contributor.authorHOFFMANN, Wolfgang
dc.contributor.authorHOLMES, Avram J
dc.contributor.authorHOMUTH, Georg
dc.contributor.authorHOSTEN, Norbert
dc.contributor.authorIKRAM, M Kamran
dc.contributor.authorIPSER, Jonathan C
dc.contributor.authorJACK, Clifford R
dc.contributor.authorJAHANSHAD, Neda
dc.contributor.authorJÖNSSON, Erik G
dc.contributor.authorKAHN, Rene S
dc.contributor.authorKANAI, Ryota
dc.contributor.authorKLEIN, Marieke
dc.contributor.authorKNOL, Maria J
dc.contributor.authorLAUNER, Lenore J
dc.contributor.authorLAWRIE, Stephen M
dc.contributor.authorHELLARD, Stephanie Le
dc.contributor.authorLEE, Phil H
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorLEMAÎTRE, Hervé
dc.contributor.authorLI, Shuo
dc.contributor.authorLIEWALD, David C M
dc.contributor.authorLIN, Honghuang
dc.contributor.authorLONGSTRETH, W T
dc.contributor.authorLOPEZ, Oscar L
dc.contributor.authorLUCIANO, Michelle
dc.contributor.authorMAILLARD, Pauline
dc.contributor.authorMARQUAND, Andre F
dc.contributor.authorMARTIN, Nicholas G
dc.contributor.authorMARTINOT, Jean-Luc
dc.contributor.authorMATHER, Karen A
dc.contributor.authorMATTAY, Venkata S
dc.contributor.authorMCMAHON, Katie L
dc.contributor.authorMECOCCI, Patrizia
dc.contributor.authorMELLE, Ingrid
dc.contributor.authorMEYER-LINDENBERG, Andreas
dc.contributor.authorMIRZA-SCHREIBER, Nazanin
dc.contributor.authorMILANESCHI, Yuri
dc.contributor.authorMOSLEY, Thomas H
dc.contributor.authorMÜHLEISEN, Thomas W
dc.contributor.authorMÜLLER-MYHSOK, Bertram
dc.contributor.authorMANIEGA, Susana Muñoz
dc.contributor.authorNAUCK, Matthias
dc.contributor.authorNHO, Kwangsik
dc.contributor.authorNIESSEN, Wiro J
dc.contributor.authorNÖTHEN, Markus M
dc.contributor.authorNYQUIST, Paul A
dc.contributor.authorOOSTERLAAN, Jaap
dc.contributor.authorPANDOLFO, Massimo
dc.contributor.authorPAUS, Tomas
dc.contributor.authorPAUSOVA, Zdenka
dc.contributor.authorPENNINX, Brenda W J H
dc.contributor.authorPIKE, G Bruce
dc.contributor.authorPSATY, Bruce M
dc.contributor.authorPÜTZ, Benno
dc.contributor.authorREPPERMUND, Simone
dc.contributor.authorRIETSCHEL, Marcella D
dc.contributor.authorRISACHER, Shannon L
dc.contributor.authorROMANCZUK-SEIFERTH, Nina
dc.contributor.authorROMERO-GARCIA, Rafael
dc.contributor.authorROSHCHUPKIN, Gennady V
dc.contributor.authorROTTER, Jerome I
dc.contributor.authorSACHDEV, Perminder S
dc.contributor.authorSÄMANN, Philipp G
dc.contributor.authorSAREMI, Arvin
dc.contributor.authorSARGURUPREMRAJ, Muralidharan
dc.contributor.authorSAYKIN, Andrew J
dc.contributor.authorSCHMAAL, Lianne
dc.contributor.authorSCHMIDT, Helena
dc.contributor.authorSCHMIDT, Reinhold
dc.contributor.authorSCHOFIELD, Peter R
dc.contributor.authorSCHOLZ, Markus
dc.contributor.authorSCHUMANN, Gunter
dc.contributor.authorSCHWARZ, Emanuel
dc.contributor.authorSHEN, Li
dc.contributor.authorSHIN, Jean
dc.contributor.authorSISODIYA, Sanjay M
dc.contributor.authorSMITH, Albert V
dc.contributor.authorSMOLLER, Jordan W
dc.contributor.authorSOININEN, Hilkka S
dc.contributor.authorSTEEN, Vidar M
dc.contributor.authorSTEIN, Dan J
dc.contributor.authorSTEIN, Jason L
dc.contributor.authorTHOMOPOULOS, Sophia I
dc.contributor.authorTOGA, Arthur W
dc.contributor.authorTORDESILLAS-GUTIÉRREZ, Diana
dc.contributor.authorTROLLOR, Julian N
dc.contributor.authorVALDES-HERNANDEZ, Maria C
dc.contributor.authorVAN T ENT, Dennis
dc.contributor.authorVAN BOKHOVEN, Hans
dc.contributor.authorVAN DER MEER, Dennis
dc.contributor.authorVAN DER WEE, Nic J A
dc.contributor.authorVÁZQUEZ-BOURGON, Javier
dc.contributor.authorVELTMAN, Dick J
dc.contributor.authorVERNOOIJ, Meike W
dc.contributor.authorVILLRINGER, Arno
dc.contributor.authorVINKE, Louis N
dc.contributor.authorVÖLZKE, Henry
dc.contributor.authorWALTER, Henrik
dc.contributor.authorWARDLAW, Joanna M
dc.contributor.authorWEINBERGER, Daniel R
dc.contributor.authorWEINER, Michael W
dc.contributor.authorWEN, Wei
dc.contributor.authorWESTLYE, Lars T
dc.contributor.authorWESTMAN, Eric
dc.contributor.authorWHITE, Tonya
dc.contributor.authorWITTE, A Veronica
dc.contributor.authorWOLF, Christiane
dc.contributor.authorYANG, Jingyun
dc.contributor.authorZWIERS, Marcel P
dc.contributor.authorIKRAM, M Arfan
dc.contributor.authorSESHADRI, Sudha
dc.contributor.authorTHOMPSON, Paul M
dc.contributor.authorSATIZABAL, Claudia L
dc.contributor.authorMEDLAND, Sarah E
dc.contributor.authorRENTERÍA, Miguel E
dc.date.accessioned2024-11-22T09:41:46Z
dc.date.available2024-11-22T09:41:46Z
dc.date.issued2024-11-01
dc.identifier.issn1546-1718en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/203440
dc.description.abstractEnSubcortical brain structures are involved in developmental, psychiatric and neurological disorders. Here we performed genome-wide association studies meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and the ventral diencephalon) in 74,898 participants of European ancestry. We identified 254 independent loci associated with these brain volumes, explaining up to 35% of phenotypic variance. We observed gene expression in specific neural cell types across differentiation time points, including genes involved in intracellular signaling and brain aging-related processes. Polygenic scores for brain volumes showed predictive ability when applied to individuals of diverse ancestries. We observed causal genetic effects of brain volumes with Parkinson's disease and attention-deficit/hyperactivity disorder. Findings implicate specific gene expression patterns in brain development and genetic variants in comorbid neuropsychiatric disorders, which could point to a brain substrate and region of action for risk genes implicated in brain diseases.
dc.language.isoENen_US
dc.subject.enHumans
dc.subject.enGenome-Wide Association Study
dc.subject.enMultifactorial Inheritance
dc.subject.enBrain
dc.subject.enFemale
dc.subject.enMale
dc.subject.enOrgan Size
dc.subject.enAttention Deficit Disorder with Hyperactivity
dc.subject.enParkinson Disease
dc.subject.enPolymorphism
dc.subject.enSingle Nucleotide
dc.subject.enGenomics
dc.subject.enAdult
dc.subject.enGenetic Predisposition to Disease
dc.subject.enMiddle Aged
dc.subject.enWhite People
dc.title.enGenomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries.
dc.title.alternativeNat Geneten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1038/s41588-024-01951-zen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed39433889en_US
bordeaux.journalNature Geneticsen_US
bordeaux.page2333-2344en_US
bordeaux.volume56en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue11en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04797532
hal.version1
hal.date.transferred2024-11-22T09:42:05Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nature%20Genetics&rft.date=2024-11-01&rft.volume=56&rft.issue=11&rft.spage=2333-2344&rft.epage=2333-2344&rft.eissn=1546-1718&rft.issn=1546-1718&rft.au=GARC%C3%8DA-MAR%C3%8DN,%20Luis%20M&CAMPOS,%20Adrian%20I&DIAZ-TORRES,%20Santiago&RABINOWITZ,%20Jill%20A&CEJA,%20Zuriel&rft.genre=article


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