pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)
LEGROS, Camille
Laboratory of Mammalian Cell Culture [GIGA-R]
Laboratoire de Chimie des Polymères Organiques [LCPO]
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Laboratory of Mammalian Cell Culture [GIGA-R]
Laboratoire de Chimie des Polymères Organiques [LCPO]
LEGROS, Camille
Laboratory of Mammalian Cell Culture [GIGA-R]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Laboratory of Mammalian Cell Culture [GIGA-R]
Laboratoire de Chimie des Polymères Organiques [LCPO]
LECOMMANDOUX, Sebastien
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 3 LCPO : Polymer Self-Assembly & Life Sciences
TATON, Daniel
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
< Reduce
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Language
en
Article de revue
This item was published in
Polymer Chemistry. 2013, vol. 4, n° 17, p. 4801-4808
Royal Society of Chemistry - RSC
English Abstract
Hydrogels and nanogels made from partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) were prepared by two different processes. First, both hydrogels and nanogels were made in dilute media in the presence of 1,6-hexanediol ...Read more >
Hydrogels and nanogels made from partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) were prepared by two different processes. First, both hydrogels and nanogels were made in dilute media in the presence of 1,6-hexanediol di-glycidyl ether (1) as the cross-linker. Alternatively, the PEtOx precursor was engineered into nanogels by an inverse w/o emulsion process. In the latter case, in addition to cross-linker 1,a cleavable cross-linker homologue (2), namely 1,6-hydroxyethyl disulfide-bis-di-glycidyl ether, was used to produce cleavable nanogels. The pH-responsiveness of all cross-linked PEtOx derivatives was demonstrated in an acidic environment, owing to the protonation of residual ethylene imine groups and/or tertiary amines formed during the cross-linking reaction. Nanogels derived from cross-linker 2 could readily be cleaved under a reducing environment, due to the presence of disulfide linkages at the cross-linking points.Read less <
English Keywords
POLYMER
POLYOXAZOLINES
2-METHYL-2-OXAZOLINE
BLOCK-COPOLYMER MICELLES
BIOMEDICAL APPLICATIONS
NONIONIC HYDROGEL
DRUG-DELIVERY
POLY(ETHYLENE GLYCOL)
SENSITIVE HYDROGELS
POLY(2-OXAZOLINE)S
Origin
Hal imported