LEGROS, Camille; DE PAUW-GILLET, Marie-Claire; TAM, Kam Chiu; LECOMMANDOUX, Sebastien; TATON, Daniel

doi:10.1039/c3py00685a

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LEGROS, Camille
Laboratory of Mammalian Cell Culture [GIGA-R]
Laboratoire de Chimie des Polymères Organiques [LCPO]

DE PAUW-GILLET, Marie-Claire
Laboratory of Mammalian Cell Culture [GIGA-R]

TAM, Kam Chiu
University of Waterloo [Waterloo]

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Polymer Chemistry. 2013, vol. 4, n° 17, p. 4801-4808

Royal Society of Chemistry - RSC

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Hydrogels and nanogels made from partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx) were prepared by two different processes. First, both hydrogels and nanogels were made in dilute media in the presence of 1,6-hexanediol di-glycidyl ether (1) as the cross-linker. Alternatively, the PEtOx precursor was engineered into nanogels by an inverse w/o emulsion process. In the latter case, in addition to cross-linker 1,a cleavable cross-linker homologue (2), namely 1,6-hydroxyethyl disulfide-bis-di-glycidyl ether, was used to produce cleavable nanogels. The pH-responsiveness of all cross-linked PEtOx derivatives was demonstrated in an acidic environment, owing to the protonation of residual ethylene imine groups and/or tertiary amines formed during the cross-linking reaction. Nanogels derived from cross-linker 2 could readily be cleaved under a reducing environment, due to the presence of disulfide linkages at the cross-linking points.< Leer menos

Palabras clave en inglés

POLYMER

POLYOXAZOLINES

2-METHYL-2-OXAZOLINE

BLOCK-COPOLYMER MICELLES

BIOMEDICAL APPLICATIONS

NONIONIC HYDROGEL

DRUG-DELIVERY

POLY(ETHYLENE GLYCOL)

SENSITIVE HYDROGELS

POLY(2-OXAZOLINE)S

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pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)

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