Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.
Language
EN
Article de revue
This item was published in
Journal of Medicinal Chemistry. 2014-06-12, vol. 57, n° 11, p. 4640-60
English Abstract
We report herein further insight into the biological activities displayed by a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs). Substitution of the N-hydroxyimide two-metal binding pharmacophore at position 4 by ...Read more >
We report herein further insight into the biological activities displayed by a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs). Substitution of the N-hydroxyimide two-metal binding pharmacophore at position 4 by carboxamido side chains was previously shown by us to be fruitful for this scaffold, since strong human immunodeficiency virus type 1 integrase (HIV-1 IN) inhibitors in the low nanomolar range associated with low micromolar anti-HIV activities were obtained. We investigated the influence of substitution at position 7 on biological activity. Introduction of electron-withdrawing functional groups such as the nitro moiety at position 7 led to a noticeable improvement of antiviral activity, down to low nanomolar anti-HIV potencies, with advantageous therapeutic indexes going close to those of the clinically used raltegravir and retained potencies against a panel of IN mutants.Read less <
English Keywords
Aryl Hydrocarbon Hydroxylases
Cell Line
Tumor
Cytochrome P-450 CYP2C9
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP3A Inhibitors
Drug Resistance
Viral
HIV Integrase Inhibitors
HIV-1
Humans
Isoquinolines
Molecular Docking Simulation
Mutation
Structure-Activity Relationship