DAUSSY, Coralie; PIED, Noémie; RAYNE, Fabienne; WODRICH, Harald

doi:10.1080/27694127.2022.2136604

Microbiologie Fondamentale et Pathogénicité [MFP]

PIED, Noémie
Microbiologie Fondamentale et Pathogénicité [MFP]

RAYNE, Fabienne

Microbiologie Fondamentale et Pathogénicité [MFP]

Idioma

Article de revue

Este ítem está publicado en

Autophagy Reports. 2022-10-25, vol. 1, n° 1, p. 551-554

Resumen en inglés

Most cell entry by invading pathogens involves penetration of either the plasma membrane or the endo-lysosomal compartment to reach the cytosol. This process frequently inflicts membrane damage and provokes a cellular response. This Autophagic Punctum summarizes our recent study investigating how adenovirus endosome penetration is recognized and activates macroautophagy/autophagy. Our key finding is that TBK1 (TANK binding kinase 1) has a dual role in the cell response to membrane damage; it is part of an immediateacting membrane-damage-sensing complex and is a crucial driver of the resulting autophagic response. Thus, TBK1 is a central factor linking sensors and effectors during the cell response to membrane damage.< Leer menos

Palabras clave en inglés

Adenovirus autophagy galectin 8 lysosomal damage membrane damage TBK1 virus entry

Adenovirus

autophagy

galectin 8

lysosomal damage

membrane damage

TBK1

virus entry

URI

https://oskar-bordeaux.fr/handle/20.500.12278/202590

DOI

http://dx.doi.org/10.1080/27694127.2022.2136604

Centros de investigación

MFP (Laboratoire Microbiologie Fondamentale et Pathogénicité) - UMR 5234

Ver/Abrir

Metadatos

Compartir este ítem

Licencia de uso del documento

The missing link : TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry

Idioma

Este ítem está publicado en

Resumen en inglés

Palabras clave en inglés

URI

DOI

Centros de investigación