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The missing link : TBK1 connects membrane damage sensing with autophagic response upon adenovirus entry
Language
EN
Article de revue
This item was published in
Autophagy Reports. 2022-10-25, vol. 1, n° 1, p. 551-554
English Abstract
Most cell entry by invading pathogens involves penetration of either the plasma membrane or the endo-lysosomal compartment to reach the cytosol. This process frequently inflicts membrane damage and provokes a cellular ...Read more >
Most cell entry by invading pathogens involves penetration of either the plasma membrane or the endo-lysosomal compartment to reach the cytosol. This process frequently inflicts membrane damage and provokes a cellular response. This Autophagic Punctum summarizes our recent study investigating how adenovirus endosome penetration is recognized and activates macroautophagy/autophagy. Our key finding is that TBK1 (TANK binding kinase 1) has a dual role in the cell response to membrane damage; it is part of an immediateacting membrane-damage-sensing complex and is a crucial driver of the resulting autophagic response. Thus, TBK1 is a central factor linking sensors and effectors during the cell response to membrane damage.Read less <
English Keywords
Adenovirus autophagy galectin 8 lysosomal damage membrane damage TBK1 virus entry
Adenovirus
autophagy
galectin 8
lysosomal damage
membrane damage
TBK1
virus entry