YASSINE, Montaha; RIFAI, Ahmad; DOUMYATI, Samah; TRIVELLA, Aurelien; MAZELLIER, Patrick; BUDZINSKI, Hélène; AL ISKANDARANI, Mohamad

doi:10.1007/s11356-017-8409-7

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YASSINE, Montaha
Environnements et Paléoenvironnements OCéaniques [EPOC]

RIFAI, Ahmad
Lebanese Atomic Energy Comission [CNRS-L] [LAEC-CNRS]

DOUMYATI, Samah
Dr. Faculté de Santé Publique, Section I, Hadath, Beyrouth, Lebanon.

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Environmental Science and Pollution Research. 2017-03, vol. 24, n° 9, p. 7982-7993

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In this study, we aimed to investigate the kinetics and the mechanism of reaction of the fluoroquinolone antibacterial danofloxacin (DANO) by free available chlorine (FAC) during water chlorination process. Kinetic study was thus performed at pH 7.2, 20 °C in the presence of an excess of total chlorine. Under these experimental conditions, a second-order reaction rate constant (first-order relative to DANO concentration and first-order relative to FAC concentration) was evaluated to k~1446 M-1 s-1. Five degradation products were identified at different reaction times. Their structures were investigated by using fragmentations obtained at different CID collision energies in MS/MS experiments. Moreover, the toxicity of the proposed structures was predicted by using T.E.S.T.< Réduire

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Chlorination

Danofloxacin

Degradation pathways

Degradation products

Kinetic study

Toxicity prediction

GEOF

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Oxidation of danofloxacin by free chlorine—kinetic study, structural identification of by-products by LC–MS/MS and potential toxicity of by-products using in silico test

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