Oxidation of danofloxacin by free chlorine—kinetic study, structural identification of by-products by LC–MS/MS and potential toxicity of by-products using in silico test
AL ISKANDARANI, Mohamad
National Council for Scientific Research = Conseil national de la recherche scientifique du Liban [Lebanon] [CNRS-L]
Dr. Faculté de Santé Publique, Section I, Hadath, Beyrouth, Lebanon.
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National Council for Scientific Research = Conseil national de la recherche scientifique du Liban [Lebanon] [CNRS-L]
Dr. Faculté de Santé Publique, Section I, Hadath, Beyrouth, Lebanon.
Language
EN
Article de revue
This item was published in
Environmental Science and Pollution Research. 2017-03, vol. 24, n° 9, p. 7982-7993
English Abstract
In this study, we aimed to investigate the kinetics and the mechanism of reaction of the fluoroquinolone antibacterial danofloxacin (DANO) by free available chlorine (FAC) during water chlorination process. Kinetic study ...Read more >
In this study, we aimed to investigate the kinetics and the mechanism of reaction of the fluoroquinolone antibacterial danofloxacin (DANO) by free available chlorine (FAC) during water chlorination process. Kinetic study was thus performed at pH 7.2, 20 °C in the presence of an excess of total chlorine. Under these experimental conditions, a second-order reaction rate constant (first-order relative to DANO concentration and first-order relative to FAC concentration) was evaluated to k~1446 M-1 s-1. Five degradation products were identified at different reaction times. Their structures were investigated by using fragmentations obtained at different CID collision energies in MS/MS experiments. Moreover, the toxicity of the proposed structures was predicted by using T.E.S.T.Read less <
English Keywords
Chlorination
Danofloxacin
Degradation pathways
Degradation products
Kinetic study
Toxicity prediction
GEOF