PICHAVANT, Loïc; CARRIÉ, Hélène; NGUYEN, Minh Ngoc; PLAWINSKI, Laurent; DURRIEU, Marie-Christine; HÉROGUEZ, Valérie

doi:10.1021/acs.biomac.5b01727

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PICHAVANT, Loïc
Laboratoire de Chimie des Polymères Organiques [LCPO]

CARRIÉ, Hélène
Laboratoire de Chimie des Polymères Organiques [LCPO]

NGUYEN, Minh Ngoc
Laboratoire de Chimie des Polymères Organiques [LCPO]
VNU Univ Sci, Fac Chem, Hanoi

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Biomacromolecules. 2016, vol. 17, n° 4, p. 1339-1346

American Chemical Society

Résumé en anglais

In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of alpha-norbornenyl-omega-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.< Réduire

Mots clés en anglais

OXIDE)

TITANIUM

ADHESION

OPENING METATHESIS POLYMERIZATION

INFECTIONS

PARTICLES

DELIVERY

EPIDERMIDIS

IMPLANTS

BIOFILMS

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Vancomycin Functionalized Nanoparticles for Bactericidal Biomaterial Surfaces

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