Vancomycin Functionalized Nanoparticles for Bactericidal Biomaterial Surfaces
NGUYEN, Minh Ngoc
Laboratoire de Chimie des Polymères Organiques [LCPO]
VNU Univ Sci, Fac Chem, Hanoi
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Laboratoire de Chimie des Polymères Organiques [LCPO]
VNU Univ Sci, Fac Chem, Hanoi
NGUYEN, Minh Ngoc
Laboratoire de Chimie des Polymères Organiques [LCPO]
VNU Univ Sci, Fac Chem, Hanoi
Laboratoire de Chimie des Polymères Organiques [LCPO]
VNU Univ Sci, Fac Chem, Hanoi
HÉROGUEZ, Valérie
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
< Reduce
Laboratoire de Chimie des Polymères Organiques [LCPO]
Team 1 LCPO : Polymerization Catalyses & Engineering
Language
en
Article de revue
This item was published in
Biomacromolecules. 2016, vol. 17, n° 4, p. 1339-1346
American Chemical Society
English Abstract
In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy ...Read more >
In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of alpha-norbornenyl-omega-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.Read less <
English Keywords
OXIDE)
TITANIUM
ADHESION
OPENING METATHESIS POLYMERIZATION
INFECTIONS
PARTICLES
DELIVERY
EPIDERMIDIS
IMPLANTS
BIOFILMS
Origin
Hal imported