SINGHAARACHCHI, Pasindu Hansana; ANTAL, Peter; CALON, Frederic; CULMSEE, Carsten; DELPECH, Jean-Christophe; FELDOTTO, Martin; GEERTSEMA, Jorine; HOEKSEMA, Emmy E.; KOROSI, Aniko; LAYE, Sophie; MCQUALTER, Jonathan; DE ROOIJ, Susanne R.; RUMMEL, Christoph; SLAYO, Mary; SOMINSKY, Luba; SPENCER, Sarah J.

doi:10.1016/j.neubiorev.2024.105724

CALON, Frederic
Nutrition et Neurobiologie intégrée [NutriNeuro]

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Article de revue

Ce document a été publié dans

Neuroscience and Biobehavioral Reviews. 2024-07-01, vol. 162, p. 105724

Résumé en anglais

Alzheimer’s disease (AD) is prevalent around the world, yet our understanding of the disease is still very limited. Recent work suggests that the cornerstone of AD may include the inflammation that accompanies it. Failure of a normal pro-inflammatory immune response to resolve may lead to persistent central inflammation that contributes to unsuccessful clearance of amyloid-beta plaques as they form, neuronal death, and ultimately cognitive decline. Individual metabolic, and dietary (lipid) profiles can differentially regulate this inflammatory process with aging, obesity, poor diet, early life stress and other inflammatory factors contributing to a greater risk of developing AD. Here, we integrate evidence for the interface between these factors, and how they contribute to a pro-inflammatory brain milieu. In particular, we discuss the importance of appropriate polyunsaturated fatty acids (PUFA) in the diet for the metabolism of specialised pro-resolving mediators (SPMs); raising the possibility for dietary strategies to improve AD outlook.< Réduire

Mots clés en anglais

Adipokine

Early-life adversity

Inflammation Lipids

Microglia

Nutrition

N-3 polyunsaturated fatty acids

Oxylipin

Specialized pro-resolving mediators

Sex

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201190

DOI

http://dx.doi.org/10.1016/j.neubiorev.2024.105724

Project ANR

Risk factors and markers for early detection of Alzheimer's Disease: focus on early-life adversity, inflammation and lipid mediators

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer’s disease research