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Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer’s disease research
Language
EN
Article de revue
This item was published in
Neuroscience and Biobehavioral Reviews. 2024-07-01, vol. 162, p. 105724
English Abstract
Alzheimer’s disease (AD) is prevalent around the world, yet our understanding of the disease is still very limited. Recent work suggests that the cornerstone of AD may include the inflammation that accompanies it. Failure ...Read more >
Alzheimer’s disease (AD) is prevalent around the world, yet our understanding of the disease is still very limited. Recent work suggests that the cornerstone of AD may include the inflammation that accompanies it. Failure of a normal pro-inflammatory immune response to resolve may lead to persistent central inflammation that contributes to unsuccessful clearance of amyloid-beta plaques as they form, neuronal death, and ultimately cognitive decline. Individual metabolic, and dietary (lipid) profiles can differentially regulate this inflammatory process with aging, obesity, poor diet, early life stress and other inflammatory factors contributing to a greater risk of developing AD. Here, we integrate evidence for the interface between these factors, and how they contribute to a pro-inflammatory brain milieu. In particular, we discuss the importance of appropriate polyunsaturated fatty acids (PUFA) in the diet for the metabolism of specialised pro-resolving mediators (SPMs); raising the possibility for dietary strategies to improve AD outlook.Read less <
English Keywords
Adipokine
Early-life adversity
Inflammation Lipids
Microglia
Nutrition
N-3 polyunsaturated fatty acids
Oxylipin
Specialized pro-resolving mediators
Sex
ANR Project
Risk factors and markers for early detection of Alzheimer's Disease: focus on early-life adversity, inflammation and lipid mediators