WALLE, Roman; PETITBON, Anna; FOIS, Giulia R; VARIN, Christophe; MONTALBAN, Enrica; HARDT, Lola; CONTINI, Andrea; ANGELO, Maria Florencia; POTIER, Mylène; ORTOLE, Rodrigue; OUMMADI, Asma; DE SMEDT-PEYRUSSE, Veronique; ADAN, Roger A; GIROS, Bruno; CHAOULOFF, Francis; FERREIRA, Guillaume; DE KERCHOVE D'EXAERDE, Alban; DUCROCQ, Fabien; GEORGES, François; TRIFILIEFF, Pierre

doi:10.1038/s41467-024-46874-9

Nutrition et Neurobiologie intégrée [NutriNeuro]

PETITBON, Anna

Nutrition et Neurobiologie intégrée [NutriNeuro]

FOIS, Giulia R

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Article de revue

Ce document a été publié dans

Nature Communications. 2024-03-21, vol. 15, n° 1, p. 2543

Résumé en anglais

Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution to ED symptomatic dimensions remains unclear. Using chemogenetic manipulations in male mice, we found that activity of dopamine D1 receptor-expressing neurons of the NAc core subregion facilitated effort for a food reward as well as voluntary exercise, but decreased food intake, while D2-expressing neurons have opposite effects. These effects are congruent with D2-neurons being more active than D1-neurons during feeding while it is the opposite during running. Chronic manipulations of each subpopulations had limited effects on energy balance. However, repeated activation of D1-neurons combined with inhibition of D2-neurons biased behavior toward activity-related energy expenditure, whilst the opposite manipulations favored energy intake. Strikingly, concomitant activation of D1-neurons and inhibition of D2-neurons precipitated weight loss in anorexia models. These results suggest that dysregulations of NAc dopaminoceptive neurons might be at the core of EDs.< Réduire

Mots clés en anglais

Mice

Male

Animals

Nucleus Accumbens

Receptors

Dopamine D2

Neurons

Receptors

Dopamine D1

Energy Metabolism

URI

https://oskar-bordeaux.fr/handle/20.500.12278/201174

DOI

http://dx.doi.org/10.1038/s41467-024-46874-9

Project ANR

Développement d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004
Initiative d'excellence de l'Université de Bordeaux
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Rôle du circuit POMC-striatum ventral dans le développement de l'obésité

Unités de recherche

NutriNeuro (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286

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Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.