Metadata
Show full item recordShare this item!
Nucleus accumbens D1- and D2-expressing neurons control the balance between feeding and activity-mediated energy expenditure.
CHAOULOFF, Francis
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
< Reduce
Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
Language
EN
Article de revue
This item was published in
Nature Communications. 2024-03-21, vol. 15, n° 1, p. 2543
English Abstract
Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution to ED symptomatic dimensions remains unclear. Using chemogenetic manipulations in ...Read more >
Accumulating evidence points to dysregulations of the Nucleus Accumbens (NAc) in eating disorders (ED), however its precise contribution to ED symptomatic dimensions remains unclear. Using chemogenetic manipulations in male mice, we found that activity of dopamine D1 receptor-expressing neurons of the NAc core subregion facilitated effort for a food reward as well as voluntary exercise, but decreased food intake, while D2-expressing neurons have opposite effects. These effects are congruent with D2-neurons being more active than D1-neurons during feeding while it is the opposite during running. Chronic manipulations of each subpopulations had limited effects on energy balance. However, repeated activation of D1-neurons combined with inhibition of D2-neurons biased behavior toward activity-related energy expenditure, whilst the opposite manipulations favored energy intake. Strikingly, concomitant activation of D1-neurons and inhibition of D2-neurons precipitated weight loss in anorexia models. These results suggest that dysregulations of NAc dopaminoceptive neurons might be at the core of EDs.Read less <
English Keywords
Mice
Male
Animals
Nucleus Accumbens
Receptors
Dopamine D2
Neurons
Receptors
Dopamine D1
Energy Metabolism
ANR Project
Développement d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004
Initiative d'excellence de l'Université de Bordeaux
Impact de la composition lipidique membranaire sur la transmission dopaminergique dépendante du récepteur D2 et la motivation - ANR-16-CE16-0022
Role du biostatus en acides gras polyinsaturés dans les troubles de contrôle exécutif
Rôle du circuit POMC-striatum ventral dans le développement de l'obésité - ANR-21-CE14-0018
Initiative d'excellence de l'Université de Bordeaux
Impact de la composition lipidique membranaire sur la transmission dopaminergique dépendante du récepteur D2 et la motivation - ANR-16-CE16-0022
Role du biostatus en acides gras polyinsaturés dans les troubles de contrôle exécutif
Rôle du circuit POMC-striatum ventral dans le développement de l'obésité - ANR-21-CE14-0018