GOUNOU, Celine; BOUVET, Flora; LIET, Benjamin; PROUZET-MAULEON, Valerie; D'AGATA, Lena; HARTE, Etienne; ARGOUL, Francoise; SIEGFRIED, Geraldine; IGGO, Richard; KHATIB, Abdel-Majid; BOUTER, Anthony

doi:10.1111/boc.202200110

GOUNOU, Celine
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

BOUVET, Flora
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]

LIET, Benjamin

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Article de revue

Ce document a été publié dans

Biology of the Cell. 2022-11-21

Résumé en anglais

Abstract Background Information During tumor invasion and metastasis processes, cancer cells are exposed to major compressive and shearing forces, due to their migration through extracellular matrix, dense cell areas, and complex fluids, which may lead to numerous plasma membrane damages. Cancer cells may survive to these mechanical stresses thanks to an efficient membrane repair machinery. Consequently, this machinery may constitute a relevant target to inhibit cancer cell dissemination. Results We show here that annexin‐A5 (ANXA5) and ANXA6 participate in membrane repair of MDA‐MB‐231 cells, a highly invasive triple‐negative breast cancer cell line. These crucial components of the membrane repair machinery are substantially expressed in breast cancer cells in correlation with their invasive properties. In addition, high expression of ANXA5 and ANXA6 predict poor prognosis in high‐grade lung, gastric, and breast cancers. In zebrafish, the genetic inhibition of ANXA5 and ANXA6 leads to drastic reduction of tumor cell dissemination. Conclusion We conclude that the inhibition of ANXA5 and ANXA6 prevents membrane repair in cancer cells, which are thus unable to survive to membrane damage during metastasis. Significance This result opens a new therapeutic strategy based on targeting membrane repair machinery to inhibit tumor invasion and metastasis.< Réduire

Mots clés en anglais

Annexins

Annexin-A5

Annexin-A6

Cancer

Invasion

Membrane repair

Metastasis

URI

https://oskar-bordeaux.fr/handle/20.500.12278/199094

DOI

http://dx.doi.org/10.1111/boc.202200110

Project ANR

Développement d'une infrastructure française distribuée coordonnée - ANR-10-INBS-0004

Unités de recherche

CBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248

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Annexin-A5 and annexin-A6 silencing prevents metastasis of breast