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Annexin-A5 and annexin-A6 silencing prevents metastasis of breast

dc.rights.licenseopenen_US
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorGOUNOU, Celine
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBOUVET, Flora
dc.contributor.authorLIET, Benjamin
dc.contributor.authorPROUZET-MAULEON, Valerie
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorD'AGATA, Lena
dc.contributor.authorHARTE, Etienne
dc.contributor.authorARGOUL, Francoise
dc.contributor.authorSIEGFRIED, Geraldine
dc.contributor.authorIGGO, Richard
dc.contributor.authorKHATIB, Abdel-Majid
hal.structure.identifierChimie et Biologie des Membranes et des Nanoobjets [CBMN]
dc.contributor.authorBOUTER, Anthony
dc.date.accessioned2024-04-16T09:55:28Z
dc.date.available2024-04-16T09:55:28Z
dc.date.issued2022-11-21
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199094
dc.description.abstractEnAbstract Background Information During tumor invasion and metastasis processes, cancer cells are exposed to major compressive and shearing forces, due to their migration through extracellular matrix, dense cell areas, and complex fluids, which may lead to numerous plasma membrane damages. Cancer cells may survive to these mechanical stresses thanks to an efficient membrane repair machinery. Consequently, this machinery may constitute a relevant target to inhibit cancer cell dissemination. Results We show here that annexin‐A5 (ANXA5) and ANXA6 participate in membrane repair of MDA‐MB‐231 cells, a highly invasive triple‐negative breast cancer cell line. These crucial components of the membrane repair machinery are substantially expressed in breast cancer cells in correlation with their invasive properties. In addition, high expression of ANXA5 and ANXA6 predict poor prognosis in high‐grade lung, gastric, and breast cancers. In zebrafish, the genetic inhibition of ANXA5 and ANXA6 leads to drastic reduction of tumor cell dissemination. Conclusion We conclude that the inhibition of ANXA5 and ANXA6 prevents membrane repair in cancer cells, which are thus unable to survive to membrane damage during metastasis. Significance This result opens a new therapeutic strategy based on targeting membrane repair machinery to inhibit tumor invasion and metastasis.
dc.description.sponsorshipDéveloppement d'une infrastructure française distribuée coordonnéeen_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enAnnexins
dc.subject.enAnnexin-A5
dc.subject.enAnnexin-A6
dc.subject.enCancer
dc.subject.enInvasion
dc.subject.enMembrane repair
dc.subject.enMetastasis
dc.title.enAnnexin-A5 and annexin-A6 silencing prevents metastasis of breast
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/boc.202200110en_US
dc.subject.halChimie/Matériauxen_US
dc.identifier.pubmed36958013en_US
bordeaux.journalBiology of the Cellen_US
bordeaux.hal.laboratoriesCBMN : Chimie & de Biologie des Membranes & des Nano-objets - UMR 5248en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biology%20of%20the%20Cell&rft.date=2022-11-21&rft.au=GOUNOU,%20Celine&BOUVET,%20Flora&LIET,%20Benjamin&PROUZET-MAULEON,%20Valerie&D'AGATA,%20Lena&rft.genre=article


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