ASSAR, Rodrigo; MONTECINO, Martín A; MAASS, Alejandro; SHERMAN, David J

doi:10.1016/j.biosystems.2014.05.007

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ASSAR, Rodrigo
Centro de Investigaciones Biomédicas
Center for Genome Regulation

MONTECINO, Martín A
Center for Genome Regulation [Santiago] [CGR]
Centro de Investigaciones Biomédicas, Facultad de Ciencias Biológicas and Facultad de Medicina

MAASS, Alejandro
Centre de modélisation mathématique / Centro de Modelamiento Matemático [Santiago] [CMM]
Centro de Regulación Génica [CRG]

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BioSystems. 2014-06-02, vol. 121, p. 43-53

Elsevier

Résumé en anglais

: In order to describe the dynamic behavior of a complex biological system, it is useful to combine models integrating processes at different levels and with temporal dependencies. Such combinations are necessary for modeling acclimatization, a phenomenon where changes in environmental conditions can induce drastic changes in the behavior of a biological system. In this article we formalize the use of hybrid systems as a tool to model this kind of biological behavior. A modeling scheme called strong switches is proposed. It allows one to take into account both minor adjustments to the coefficients of a continuous model, and, more interestingly, large-scale changes to the structure of the model. We illustrate the proposed methodology with two applications: acclimatization in wine fermentation kinetics, and acclimatization of osteo-adipo differentiation system linking stimulus signals to bone mass.< Réduire

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Acclimatization

Hybrid systems

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Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models.

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