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Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models.
| hal.structure.identifier | Centro de Investigaciones Biomédicas | |
| hal.structure.identifier | Center for Genome Regulation | |
| dc.contributor.author | ASSAR, Rodrigo | |
| hal.structure.identifier | Center for Genome Regulation [Santiago] [CGR] | |
| hal.structure.identifier | Centro de Investigaciones Biomédicas, Facultad de Ciencias Biológicas and Facultad de Medicina | |
| dc.contributor.author | MONTECINO, Martín A | |
| hal.structure.identifier | Centre de modélisation mathématique / Centro de Modelamiento Matemático [Santiago] [CMM] | |
| hal.structure.identifier | Centro de Regulación Génica [CRG] | |
| dc.contributor.author | MAASS, Alejandro | |
| hal.structure.identifier | Laboratoire Bordelais de Recherche en Informatique [LaBRI] | |
| hal.structure.identifier | Models and Algorithms for the Genome [MAGNOME] | |
| dc.contributor.author | SHERMAN, David J | |
| dc.date.accessioned | 2024-04-15T09:58:16Z | |
| dc.date.available | 2024-04-15T09:58:16Z | |
| dc.date.issued | 2014-06-02 | |
| dc.identifier.issn | 0303-2647 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/198987 | |
| dc.description.abstractEn | : In order to describe the dynamic behavior of a complex biological system, it is useful to combine models integrating processes at different levels and with temporal dependencies. Such combinations are necessary for modeling acclimatization, a phenomenon where changes in environmental conditions can induce drastic changes in the behavior of a biological system. In this article we formalize the use of hybrid systems as a tool to model this kind of biological behavior. A modeling scheme called strong switches is proposed. It allows one to take into account both minor adjustments to the coefficients of a continuous model, and, more interestingly, large-scale changes to the structure of the model. We illustrate the proposed methodology with two applications: acclimatization in wine fermentation kinetics, and acclimatization of osteo-adipo differentiation system linking stimulus signals to bone mass. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.subject.en | Acclimatization | |
| dc.subject.en | Hybrid systems | |
| dc.title.en | Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models. | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.biosystems.2014.05.007 | |
| dc.subject.hal | Informatique [cs]/Bio-informatique [q-bio.QM] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM] | |
| dc.subject.hal | Mathématiques [math]/Systèmes dynamiques [math.DS] | |
| bordeaux.journal | BioSystems | |
| bordeaux.page | 43-53 | |
| bordeaux.volume | 121 | |
| bordeaux.hal.laboratories | Laboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01002987 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01002987v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BioSystems&rft.date=2014-06-02&rft.volume=121&rft.spage=43-53&rft.epage=43-53&rft.eissn=0303-2647&rft.issn=0303-2647&rft.au=ASSAR,%20Rodrigo&MONTECINO,%20Mart%C3%ADn%20A&MAASS,%20Alejandro&SHERMAN,%20David%20J&rft.genre=article |
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