Genome-scale Metabolic Reconstruction of the Eukaryote Cell Factory Yarrowia Lipolytica
LOIRA, Nicolás
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
SHERMAN, David James
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
LOIRA, Nicolás
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
SHERMAN, David James
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
< Réduire
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
Langue
en
Communication dans un congrès
Ce document a été publié dans
11th International Conference on Systems Biology, 2010-10, Edinburgh. 2010-10
Résumé en anglais
Yarrowia lipolytica is an oleaginous yeast studied experimentally for its role as a food contaminant and its use in bioremediation and cell factory applications. As one of the hemiascomycetous yeasts completely sequenced ...Lire la suite >
Yarrowia lipolytica is an oleaginous yeast studied experimentally for its role as a food contaminant and its use in bioremediation and cell factory applications. As one of the hemiascomycetous yeasts completely sequenced in the Génolevures program it enjoys a high quality manual annotation by a network of experts. We have developed a method of semi-automatic reconstruction of metabolic models, based on the prediction of conservation of enzymatic activities between two species. Following our reconstruction protocol, we extrapolated a Y.lipolytica genome-scale metabolic model (called iNL705) from an existing S.cerevisiae model (iND750). This draft model was curated by a group of experts in Y. lipolytica metabolism, and iteratively improved and validated through comparison with experimental data by flux balance analysis.< Réduire
Mots clés en anglais
systems biology
comparative genomics
metabolic modeling
Origine
Importé de halUnités de recherche