Genome-scale Metabolic Reconstruction of the Eukaryote Cell Factory Yarrowia Lipolytica
| hal.structure.identifier | Models and Algorithms for the Genome [ MAGNOME] | |
| hal.structure.identifier | Laboratoire Bordelais de Recherche en Informatique [LaBRI] | |
| dc.contributor.author | LOIRA, Nicolás | |
| hal.structure.identifier | Laboratoire Bordelais de Recherche en Informatique [LaBRI] | |
| hal.structure.identifier | Models and Algorithms for the Genome [ MAGNOME] | |
| dc.contributor.author | SHERMAN, David James | |
| dc.date.accessioned | 2024-04-15T09:46:07Z | |
| dc.date.available | 2024-04-15T09:46:07Z | |
| dc.date.issued | 2010-10 | |
| dc.date.conference | 2010-10 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/197980 | |
| dc.description.abstractEn | Yarrowia lipolytica is an oleaginous yeast studied experimentally for its role as a food contaminant and its use in bioremediation and cell factory applications. As one of the hemiascomycetous yeasts completely sequenced in the Génolevures program it enjoys a high quality manual annotation by a network of experts. We have developed a method of semi-automatic reconstruction of metabolic models, based on the prediction of conservation of enzymatic activities between two species. Following our reconstruction protocol, we extrapolated a Y.lipolytica genome-scale metabolic model (called iNL705) from an existing S.cerevisiae model (iND750). This draft model was curated by a group of experts in Y. lipolytica metabolism, and iteratively improved and validated through comparison with experimental data by flux balance analysis. | |
| dc.language.iso | en | |
| dc.subject.en | systems biology | |
| dc.subject.en | comparative genomics | |
| dc.subject.en | metabolic modeling | |
| dc.title.en | Genome-scale Metabolic Reconstruction of the Eukaryote Cell Factory Yarrowia Lipolytica | |
| dc.type | Communication dans un congrès | |
| dc.subject.hal | Informatique [cs]/Bio-informatique [q-bio.QM] | |
| dc.subject.hal | Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM] | |
| bordeaux.hal.laboratories | Laboratoire Bordelais de Recherche en Informatique (LaBRI) - UMR 5800 | * |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.conference.title | 11th International Conference on Systems Biology | |
| bordeaux.country | GB | |
| bordeaux.conference.city | Edinburgh | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00652922 | |
| hal.version | 1 | |
| hal.invited | non | |
| hal.proceedings | non | |
| hal.conference.organizer | ICSB | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00652922v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2010-10&rft.au=LOIRA,%20Nicol%C3%A1s&SHERMAN,%20David%20James&rft.genre=unknown |
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