The complete genome of Blastobotrys (Arxula) adeninivorans LS3 - a yeast of biotechnological interest.
KUNZE, Gotthard
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Yeast Genetics
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Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Yeast Genetics
KUNZE, Gotthard
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Yeast Genetics
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Yeast Genetics
DURRENS, Pascal
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
MARTIN, Tiphaine
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
BÖER, Erik
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
BEIER, Sebastian
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
GIERSBERG, Martin
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
HÄHNEL, Urs
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
HARTMANN, Anja
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
JANKOWSKA, Dagmara
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
MARCET-HOUBEN, Marina
Bioinformatics and Genomics Programme
Universitat Pompeu Fabra [Barcelona] [UPF]
Bioinformatics and Genomics Programme
Universitat Pompeu Fabra [Barcelona] [UPF]
MASCHER, Martin
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
RIECHEN, Jan
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
SHERMAN, David
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Models and Algorithms for the Genome [ MAGNOME]
STEIN, Nils
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
TRAUTWEIN-SCHULT, Anke
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
WORCH, Sebastian
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
SCHOLZ, Uwe
Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
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Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] [IPK-Gatersleben]
Langue
en
Article de revue
Ce document a été publié dans
Biotechnology for Biofuels. 2014, vol. 7, n° 1, p. 66
BioMed Central
Résumé en anglais
BACKGROUND: The industrially important yeast Blastobotrys (Arxula) adeninivorans is an asexual hemiascomycete phylogenetically very distant from Saccharomyces cerevisiae. Its unusual metabolic flexibility allows it to use ...Lire la suite >
BACKGROUND: The industrially important yeast Blastobotrys (Arxula) adeninivorans is an asexual hemiascomycete phylogenetically very distant from Saccharomyces cerevisiae. Its unusual metabolic flexibility allows it to use a wide range of carbon and nitrogen sources, while being thermotolerant, xerotolerant and osmotolerant. RESULTS: The sequencing of strain LS3 revealed that the nuclear genome of A. adeninivorans is 11.8 Mb long and consists of four chromosomes with regional centromeres. Its closest sequenced relative is Yarrowia lipolytica, although mean conservation of orthologs is low. With 914 introns within 6116 genes, A. adeninivorans is one of the most intron-rich hemiascomycetes sequenced to date. Several large species-specific families appear to result from multiple rounds of segmental duplications of tandem gene arrays, a novel mechanism not yet described in yeasts. An analysis of the genome and its transcriptome revealed enzymes with biotechnological potential, such as two extracellular tannases (Atan1p and Atan2p) of the tannic-acid catabolic route, and a new pathway for the assimilation of n-butanol via butyric aldehyde and butyric acid. CONCLUSIONS: The high-quality genome of this species that diverged early in Saccharomycotina will allow further fundamental studies on comparative genomics, evolution and phylogenetics. Protein components of different pathways for carbon and nitrogen source utilization were identified, which so far has remained unexplored in yeast, offering clues for further biotechnological developments. In the course of identifying alternative microorganisms for biotechnological interest, A. adeninivorans has already proved its strengthened competitiveness as a promising cell factory for many more applications.< Réduire
Mots clés
n-butanol
biotechnology
Mots clés en anglais
yeast
genome
tannic acid
metabolism
Origine
Importé de halUnités de recherche