Percolation as a mechanism to explain atrial fractionated electrograms and reentry in a fibrosis model based on imaging data
Language
en
Article de revue
This item was published in
Heart Rhythm. 2016-07, vol. 13, n° 7, p. 1536-1543
Elsevier
English Abstract
Complex fractionated atrial electrograms (CFAEs) have long been associated with proarrhythmic alterations in atrial structure or electrophysiology. Structural alterations disrupt and slow smoothly propagating wavefronts, ...Read more >
Complex fractionated atrial electrograms (CFAEs) have long been associated with proarrhythmic alterations in atrial structure or electrophysiology. Structural alterations disrupt and slow smoothly propagating wavefronts, leading to wavebreaks and electrogram (EGM) fractionation, but the exact nature and characteristics for arrhythmia remain unknown. Clinically, in atrial fibrillation (AF) patients, increases in frequency, whether by pacing or fibrillation, increase EGM fractionation and duration, and reentry can occur in relation with the conduction disturbance. Recently, percolation has been proposed as an arrhythmogenic mechanism, but its role in AF has not been investigated.Read less <
English Keywords
Atrial fibrillation
Atrial fibrosis
Cardiac electrophysiology
Computer modeling
DE-MRI
Fractionated electrogram
Percolation
Origin
Hal imported