VIGMOND, Edward; PASHAEI, Ali; AMRAOUI, Sana; COCHET, Hubert; HASSAGUERRE, Michel

doi:10.1016/j.hrthm.2016.03.019

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VIGMOND, Edward
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]

PASHAEI, Ali
Center for Computational Imaging and Simulation Technologies in Biomedicine [CISTIB]

AMRAOUI, Sana
Hôpital Haut-Lévêque [CHU Bordeaux]

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Heart Rhythm. 2016-07, vol. 13, n° 7, p. 1536-1543

Elsevier

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Complex fractionated atrial electrograms (CFAEs) have long been associated with proarrhythmic alterations in atrial structure or electrophysiology. Structural alterations disrupt and slow smoothly propagating wavefronts, leading to wavebreaks and electrogram (EGM) fractionation, but the exact nature and characteristics for arrhythmia remain unknown. Clinically, in atrial fibrillation (AF) patients, increases in frequency, whether by pacing or fibrillation, increase EGM fractionation and duration, and reentry can occur in relation with the conduction disturbance. Recently, percolation has been proposed as an arrhythmogenic mechanism, but its role in AF has not been investigated.< Leer menos

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Atrial fibrillation

Atrial fibrosis

Cardiac electrophysiology

Computer modeling

DE-MRI

Fractionated electrogram

Percolation

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Percolation as a mechanism to explain atrial fractionated electrograms and reentry in a fibrosis model based on imaging data

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