A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agent
Language
en
Article de revue
This item was published in
Journal of Theoretical Biology. 2006, vol. 243, n° 4, p. 532-541
Elsevier
English Abstract
With the aim of inhibiting cancer growth and reducing the risk of metastasis, pharmaceutical companies in the early 1990s developed anti-metastatic agents called inhibitors of metalloproteinases (MMPi). Despite the promising ...Read more >
With the aim of inhibiting cancer growth and reducing the risk of metastasis, pharmaceutical companies in the early 1990s developed anti-metastatic agents called inhibitors of metalloproteinases (MMPi). Despite the promising results obtained in pre-clinical studies, results of Phase III trials have been somewhat disappointing for late stage cancer patients. With the aim of mathematically investigating this therapeutic failure, we developed a mechanistically based model which integrates cell cycle regulation and macroscopic tumor dynamics. By simulating the model, we evaluated the efficacy of MMPi therapy. Simulation results predict the lack of efficacy of MMPi in advanced cancer patients. The theoretical model may aid in evaluating the efficacy of anti-metastatic therapies, thus benefiting the design of prospective clinical trials.Read less <
English Keywords
Mathematical modeling
Therapeutic development
Inhibitors of Metalloproteinases
Cytostatic agents
Origin
Hal imported