A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agent
| hal.structure.identifier | Numerical Medicine [NUMED] | |
| dc.contributor.author | RIBBA, Benjamin | |
| hal.structure.identifier | Institut de Mathématiques de Bordeaux [IMB] | |
| hal.structure.identifier | Modélisation, contrôle et calcul [MC2] | |
| dc.contributor.author | SAUT, Olivier | |
| dc.contributor.author | BRESCH, Didier | |
| hal.structure.identifier | Unité de Mathématiques Pures et Appliquées [UMPA-ENSL] | |
| dc.contributor.author | GRENIER, Emmanuel | |
| hal.structure.identifier | Estimation et modélisation du bénéfice thérapeutique chez l'homme | |
| dc.contributor.author | BOISSEL, Jean-Pierre | |
| dc.date.accessioned | 2024-04-04T02:48:41Z | |
| dc.date.available | 2024-04-04T02:48:41Z | |
| dc.date.issued | 2006 | |
| dc.identifier.issn | 0022-5193 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/191761 | |
| dc.description.abstractEn | With the aim of inhibiting cancer growth and reducing the risk of metastasis, pharmaceutical companies in the early 1990s developed anti-metastatic agents called inhibitors of metalloproteinases (MMPi). Despite the promising results obtained in pre-clinical studies, results of Phase III trials have been somewhat disappointing for late stage cancer patients. With the aim of mathematically investigating this therapeutic failure, we developed a mechanistically based model which integrates cell cycle regulation and macroscopic tumor dynamics. By simulating the model, we evaluated the efficacy of MMPi therapy. Simulation results predict the lack of efficacy of MMPi in advanced cancer patients. The theoretical model may aid in evaluating the efficacy of anti-metastatic therapies, thus benefiting the design of prospective clinical trials. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.rights.uri | http://creativecommons.org/licenses/by/ | |
| dc.subject.en | Mathematical modeling | |
| dc.subject.en | Therapeutic development | |
| dc.subject.en | Inhibitors of Metalloproteinases | |
| dc.subject.en | Cytostatic agents | |
| dc.title.en | A multiscale mathematical model of avascular tumor growth to investigate the therapeutic benefit of anti-invasive agent | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.jtbi.2006.07.013 | |
| dc.subject.hal | Mathématiques [math]/Equations aux dérivées partielles [math.AP] | |
| bordeaux.journal | Journal of Theoretical Biology | |
| bordeaux.page | 532-541 | |
| bordeaux.volume | 243 | |
| bordeaux.hal.laboratories | Institut de Mathématiques de Bordeaux (IMB) - UMR 5251 | * |
| bordeaux.issue | 4 | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | CNRS | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00385848 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00385848v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Theoretical%20Biology&rft.date=2006&rft.volume=243&rft.issue=4&rft.spage=532-541&rft.epage=532-541&rft.eissn=0022-5193&rft.issn=0022-5193&rft.au=RIBBA,%20Benjamin&SAUT,%20Olivier&BRESCH,%20Didier&GRENIER,%20Emmanuel&BOISSEL,%20Jean-Pierre&rft.genre=article |
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