Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
POTSE, Mark
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
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IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
POTSE, Mark
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
< Reduce
IHU-LIRYC
Modélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
Institut de Mathématiques de Bordeaux [IMB]
Language
en
Article de revue
This item was published in
Frontiers in Physiology. 2021-03-23, vol. 12, p. 648396
Frontiers
English Abstract
Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that ...Read more >
Ablation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.Read less <
English Keywords
Idiopathic ventricular fibrillation
Arrhythmias
Early repolarization syndrome
Purkinje
Ablation
Electrophysiology
ANR Project
L'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
Origin
Hal imported