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Why Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis

hal.structure.identifierIHU-LIRYC
hal.structure.identifierDepartment of Experimental Cardiology, Amsterdam University Medical Center
dc.contributor.authorCORONEL, Ruben
hal.structure.identifierIHU-LIRYC
hal.structure.identifierModélisation et calculs pour l'électrophysiologie cardiaque [CARMEN]
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorPOTSE, Mark
hal.structure.identifierIHU-LIRYC
dc.contributor.authorHAÏSSAGUERRE, Michel
hal.structure.identifierIHU-LIRYC
dc.contributor.authorDERVAL, Nicolas
hal.structure.identifierDepartment of Experimental Cardiology, Amsterdam University Medical Center
dc.contributor.authorRIVAUD, Mathilde
hal.structure.identifierDepartment of Experimental Cardiology, Amsterdam University Medical Center
dc.contributor.authorMEIJBORG, Veronique
hal.structure.identifierDepartment of Experimental Cardiology, Amsterdam University Medical Center
dc.contributor.authorCLUITMANS, Matthijs
hal.structure.identifierIHU-LIRYC
dc.contributor.authorHOCINI, Mélèze
hal.structure.identifierDepartment of Medical Biology, Amsterdam University Medical Center
dc.contributor.authorBOUKENS, Bastiaan
dc.date.accessioned2024-04-04T02:43:50Z
dc.date.available2024-04-04T02:43:50Z
dc.date.issued2021-03-23
dc.identifier.issn1664-042X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/191361
dc.description.abstractEnAblation of sites showing Purkinje activity is antiarrhythmic in some patients with idiopathic ventricular fibrillation (iVF). The mechanism for the therapeutic success of ablation is not fully understood. We propose that deeper penetrance of the Purkinje network allows faster activation of the ventricles and is proarrhythmic in the presence of steep repolarization gradients. Reduction of Purkinje penetrance, or its indirect reducing effect on apparent propagation velocity may be a therapeutic target in patients with iVF.
dc.description.sponsorshipL'Institut de Rythmologie et modélisation Cardiaque - ANR-10-IAHU-0004
dc.language.isoen
dc.publisherFrontiers
dc.subject.enIdiopathic ventricular fibrillation
dc.subject.enArrhythmias
dc.subject.enEarly repolarization syndrome
dc.subject.enPurkinje
dc.subject.enAblation
dc.subject.enElectrophysiology
dc.title.enWhy Ablation of Sites With Purkinje Activation Is Antiarrhythmic: The Interplay Between Fast Activation and Arrhythmogenesis
dc.typeArticle de revue
dc.identifier.doi10.3389/fphys.2021.648396
dc.subject.halSciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire
bordeaux.journalFrontiers in Physiology
bordeaux.page648396
bordeaux.volume12
bordeaux.hal.laboratoriesInstitut de Mathématiques de Bordeaux (IMB) - UMR 5251*
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionBordeaux INP
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
hal.identifierhal-03452281
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03452281v1
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