Artificial intelligence in CT for quantifying lung changes in the era of CFTR modulators
DOURNES, Gael
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
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Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
DOURNES, Gael
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
DENIS DE SENNEVILLE, Baudouin
Institut de Mathématiques de Bordeaux [IMB]
Modélisation Mathématique pour l'Oncologie [MONC]
Institut de Mathématiques de Bordeaux [IMB]
Modélisation Mathématique pour l'Oncologie [MONC]
BERGER, Patrick
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
LAURENT, François
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
BENLALA, Ilyes
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
< Leer menos
Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] [CRCTB]
CIC Bordeaux
CHU Bordeaux
Idioma
en
Article de revue
Este ítem está publicado en
European Respiratory Journal. 2022, vol. 59, p. 2100844
European Respiratory Society
Resumen en inglés
Background: Chest computed tomography (CT) remains the imaging standard for demonstrating cystic fibrosis (CF) airway structural disease in vivo. However, visual scoring systems as an outcome measure are time consuming, ...Leer más >
Background: Chest computed tomography (CT) remains the imaging standard for demonstrating cystic fibrosis (CF) airway structural disease in vivo. However, visual scoring systems as an outcome measure are time consuming, require training and lack high reproducibility. Our objective was to validate a fully automated artificial intelligence (AI)-driven scoring system of CF lung disease severity.Methods: Data were retrospectively collected in three CF reference centres, between 2008 and 2020, in 184 patients aged 4-54 years. An algorithm using three 2D convolutional neural networks was trained with 78 patients' CT scans (23 530 CT slices) for the semantic labelling of bronchiectasis, peribronchial thickening, bronchial mucus, bronchiolar mucus and collapse/consolidation. 36 patients' CT scans (11 435 CT slices) were used for testing versus ground-truth labels. The method's clinical validity was assessed in an independent group of 70 patients with or without lumacaftor/ivacaftor treatment (n=10 and n=60, respectively) with repeat examinations. Similarity and reproducibility were assessed using the Dice coefficient, correlations using the Spearman test, and paired comparisons using the Wilcoxon rank test.Results: The overall pixelwise similarity of AI-driven versus ground-truth labels was good (Dice 0.71). All AI-driven volumetric quantifications had moderate to very good correlations to a visual imaging scoring (p<0.001) and fair to good correlations to forced expiratory volume in 1 s % predicted at pulmonary function tests (p<0.001). Significant decreases in peribronchial thickening (p=0.005), bronchial mucus (p=0.005) and bronchiolar mucus (p=0.007) volumes were measured in patients with lumacaftor/ivacaftor. Conversely, bronchiectasis (p=0.002) and peribronchial thickening (p=0.008) volumes increased in patients without lumacaftor/ivacaftor. The reproducibility was almost perfect (Dice >0.99).Conclusion: AI allows fully automated volumetric quantification of CF-related modifications over an entire lung. The novel scoring system could provide a robust disease outcome in the era of effective CF transmembrane conductance regulator modulator therapy.< Leer menos
Proyecto ANR
Translational Research and Advanced Imaging Laboratory - ANR-10-LABX-0057
Orígen
Importado de HalCentros de investigación