The mitogaligin protein is addressed to the nucleus via a non-classical localization signal
Language
en
Article de revue
This item was published in
Biochemical and Biophysical Research Communications. 2010, vol. 392, n° 1, p. 53-57
Elsevier
English Abstract
Mitogaligin, a protein encoded by galig, an internal cytotoxic gene of the galectin-3 locus, is mostly a mitochondrial protein. Mitochondrial targeting is due to an already identified mitochondrial localization signal. ...Read more >
Mitogaligin, a protein encoded by galig, an internal cytotoxic gene of the galectin-3 locus, is mostly a mitochondrial protein. Mitochondrial targeting is due to an already identified mitochondrial localization signal. Interaction of mitogaligin with mitochondria leads to cytochrome c cytosolic leakage and ultimately to cell death. We have previously pointed out that mitogaligin can also be directed to the nucleus when the mitochondrial addressing signal is inactivated, indicating a possible dual intracellular localization of the protein. When expressed in the nucleus, mitogaligin exhibits also apoptotic properties leading to cell death. In this report, we show that nuclear addressing of mitogaligin depends on a sequence differing from classical signals containing basic, lysine or proline-tyrosine rich residues. The signal consists of a long sequence of amino acids residues based on a series of a short repetitive degenerated sequence.Read less <
Italian Keywords
Unconventional nuclear localization signal
Mitogaligin
Dual localization
CELL-DEATH PROTEIN
INTRACELLULAR-LOCALIZATION
MOLECULAR-CLONING
IDENTIFICATION
SEQUENCE
IMPORTIN
VIRUS
GENE
TRANSLOCATION
MITOCHONDRIA
Origin
Hal imported